Results 31 to 40 of about 618,570 (321)

An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]

, 2005
Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Buxton, RS, Colston, MJ, Curry, JM, Gohil, K, Hunt, DM, Rickman, L, Smerdon, SJ, Strom, M, Whalan, R   +8 more
core   +2 more sources

Bacteriophages as Potential Clinical Immune Modulators

Microorganisms, 2023
Bacteriophages (phages for short) are bacteria-specific viruses that have been drawing attention when it comes to countering the ever-growing antibiotic bacterial resistance, and are being seen as one of the most promising technologies against multi ...
Estêvão Brasiliense de Souza, Aguinaldo Roberto Pinto, Gislaine Fongaro   +2 more
doaj   +1 more source

Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]

, 2016
Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina, Chu, Jennifer, Pelletier, Jerry, Porco, John A., Wang, Wenyu   +4 more
core   +1 more source

Ras inhibitors gate chemoattractant concentration range for chemotaxis through controlling GPCR-mediated adaptation and cell sensitivity

Frontiers in Immunology, 2022
Chemotaxis plays an essential role in recruitment of leukocytes to sites of inflammation. Eukaryotic cells sense chemoattractant with G protein-coupled receptors (GPCRs) and chemotax toward gradients with an enormous concentration range through ...
Xuehua Xu, Tian Jin
doaj   +1 more source

Microbiology: Mind the gaps in cellular evolution [PDF]

, 2017
Eukaryotic cells, with complex features such as membrane-bound nuclei, evolved from prokaryotic cells that lack these components.
A Brady, A Spang, J McInerney, JA Fuhrman, James O. McInerney, JO McInerney, K Zaremba-Niedzwiedzka, KW Seitz, Mary J. O'Connell, Natalya Yutin, WF Martin   +10 more
core   +2 more sources

Defining acceptance criteria for silver nanoparticles: correlating synthesis quality with biological outcomes in an In Vitro Lung Cancer Model

Nano Trends
Lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the need for innovative therapeutic strategies. This study explores the development and evaluation of silver nanoparticles (AgNPs) synthesized under optimized heating
Bárbara Gomes, Marjorie Dardis Murucci, Wanderson de Souza, Beatriz Kopke Dal-Cheri, Ana Resende, Natália Yoshihara, Luths Geaquinto, José Mauro Granjeiro, Celso Sant'Anna, Leonardo Boldrini   +9 more
doaj   +1 more source

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia

Technology in Cancer Research & Treatment, 2020
Objective: This study aimed to explore whether eukaryotic translation elongation factor 1 alpha 2 affected cell proliferation, migration, and apoptosis via regulating the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 in ...
Shan Xiao MM, Yanping Wang MM, Yuwen Ma MM, Jue Liu MD, Can’e Tang MD, Aiping Deng MB, Chunxiang Fang MB   +6 more
doaj   +1 more source

SF3b4: A Versatile Player in Eukaryotic Cells

Frontiers in Cell and Developmental Biology, 2020
Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
doaj   +1 more source

Functional capacity of Shiga-toxin promoter sequences in eukaryotic cells. [PDF]

PLoS ONE, 2013
Shiga toxins (Stx) are the main virulence factors in enterohemorrhagic Escherichia coli (EHEC) infections, causing diarrhea and hemolytic uremic syndrome (HUS). The genes encoding for Shiga toxin-2 (Stx2) are located in a bacteriophage.
Leticia V Bentancor, Marcos F Bilen, María P Mejías, Romina J Fernández-Brando, Cecilia A Panek, Maria V Ramos, Gabriela C Fernández, Martín Isturiz, Pablo D Ghiringhelli, Marina S Palermo   +9 more
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources