Results 41 to 50 of about 606,087 (302)

Ras inhibitors gate chemoattractant concentration range for chemotaxis through controlling GPCR-mediated adaptation and cell sensitivity

open access: yesFrontiers in Immunology, 2022
Chemotaxis plays an essential role in recruitment of leukocytes to sites of inflammation. Eukaryotic cells sense chemoattractant with G protein-coupled receptors (GPCRs) and chemotax toward gradients with an enormous concentration range through ...
Xuehua Xu, Tian Jin
doaj   +1 more source

The Unicellular State as a Point Source in a Quantum Biological System. [PDF]

open access: yes, 2016
A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core   +3 more sources

SF3b4: A Versatile Player in Eukaryotic Cells

open access: yesFrontiers in Cell and Developmental Biology, 2020
Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
doaj   +1 more source

Bacteriophages as Potential Clinical Immune Modulators

open access: yesMicroorganisms, 2023
Bacteriophages (phages for short) are bacteria-specific viruses that have been drawing attention when it comes to countering the ever-growing antibiotic bacterial resistance, and are being seen as one of the most promising technologies against multi ...
Estêvão Brasiliense de Souza   +2 more
doaj   +1 more source

Unraveling Adaptation in Eukaryotic Pathways: Lessons from Protocells [PDF]

open access: yes, 2013
Eukaryotic adaptation pathways operate within wide-ranging environmental conditions without stimulus saturation. Despite numerous differences in the adaptation mechanisms employed by bacteria and eukaryotes, all require energy consumption.
De Palo, Giovanna, Endres, Robert G.
core   +4 more sources

Defining acceptance criteria for silver nanoparticles: correlating synthesis quality with biological outcomes in an In Vitro Lung Cancer Model

open access: yesNano Trends
Lung cancer remains a leading cause of cancer-related mortality worldwide, underscoring the need for innovative therapeutic strategies. This study explores the development and evaluation of silver nanoparticles (AgNPs) synthesized under optimized heating
Bárbara Gomes   +9 more
doaj   +1 more source

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia

open access: yesTechnology in Cancer Research & Treatment, 2020
Objective: This study aimed to explore whether eukaryotic translation elongation factor 1 alpha 2 affected cell proliferation, migration, and apoptosis via regulating the dimethylation of eukaryotic translation elongation factor 1 alpha at lysine 55 in ...
Shan Xiao MM   +6 more
doaj   +1 more source

Functional capacity of Shiga-toxin promoter sequences in eukaryotic cells. [PDF]

open access: yesPLoS ONE, 2013
Shiga toxins (Stx) are the main virulence factors in enterohemorrhagic Escherichia coli (EHEC) infections, causing diarrhea and hemolytic uremic syndrome (HUS). The genes encoding for Shiga toxin-2 (Stx2) are located in a bacteriophage.
Leticia V Bentancor   +9 more
doaj   +1 more source

A systematic approach to cancer: evolution beyond selection. [PDF]

open access: yes, 2017
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems.
Miller, William B, Torday, John S
core   +1 more source

A trans-kingdom T6SS effector induces the fragmentation of the mitochondrial network and activates innate immune receptor NLRX1 to promote infection

open access: yesNature Communications, 2023
Bacteria can affect cellular processes in other bacteria and in eukaryotic cells by injecting effectors using a type VI secretion system (T6SS). Here, Sá-Pessoa et al.
Joana Sá-Pessoa   +11 more
doaj   +1 more source

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