Results 61 to 70 of about 5,903,550 (301)

Building bundles by the numbers

eLife
The size and shape of cytoskeletal bundles, essential regulators of cell function, emerge from collective filament assembly rather than precise size-control mechanisms.
Christian Vanhille-Campos, Anđela Šarić   +1 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Eukaryotic response to hypothermia in relation to integrated stress responses

, 2020
Eukaryotic cells respond to hypothermic stress through a series of regulatory mechanisms that preserve energy resources and prolong cell survival. These mechanisms include alterations in gene expression, attenuated global protein synthesis and changes in
Adjirackor, N. A., Harvey, S. C., Harvey, K. E., Adjirackor, Naki A., Harvey, Simon C., Harvey, Katie E.   +5 more
core   +1 more source

Phagocytosis-like cell engulfment by a planctomycete bacterium

Nature Communications, 2019
Phagocytosis is a typically eukaryotic feature that could be behind the origin of eukaryotic cells. Here, the authors describe a bacterium that can engulf other bacteria and small eukaryotic cells through a phagocytosis-like mechanism.
Takashi Shiratori, Shigekatsu Suzuki, Yukako Kakizawa, Ken-ichiro Ishida   +3 more
doaj   +1 more source

A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector

Cell Reports, 2019
Summary: Many bacteria interact with target organisms using syringe-like structures called contractile injection systems (CISs). CISs structurally resemble headless bacteriophages and share evolutionarily related proteins such as the tail tube, sheath ...
Iara Rocchi, Charles F. Ericson, Kyle E. Malter, Sahar Zargar, Fabian Eisenstein, Martin Pilhofer, Sinem Beyhan, Nicholas J. Shikuma   +7 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Photochemical Closed-Loop Ozone-Generating System for Medicine Application

Journal of Biomedical Photonics & Engineering
This article introduces a cutting-edge device that could potentially be used to therapy of septic wounds in prospect. The circulation of ozonized air with concentrations of up to 60 ppm provided under a hermetic ozonation application chamber ...
Dmitry V. Schitz, Stanislav A. Sukhikh, Valeria V. Shupletsova, Yuri V. Voyteshonok, Mikhail A. Agapov, Olga O. Babich, Olga G. Khaziakhmatova   +6 more
doaj   +1 more source

Bacterial toxin effector membrane targeting: Outside in, then back again.

Frontiers in Cellular and Infection Microbiology, 2012
Pathogenic bacteria utilize multiple approaches to mediate their toxicity to eukaryotic cells. Dedicated protein machines deposit toxic effectors directly inside the host, whereas secreted toxins must enter cells independently of other bacterial ...
Brett eGeissler
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

What drove bacterial cells to adopt an intracellular lifestyle in eukaryotic cells during pathogenesis?

, 2020
Many bacteria invade eukaryotic cells and grow within the larger host cells. This typically results in pathogenesis and an intracellular infection, often detrimental to the host cells.
Wenfa Ng (444092)
core   +1 more source