Results 81 to 90 of about 387,698 (305)

Sphingolipid transport in eukaryotic cells [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000
Sphingolipids constitute a sizeable fraction of the membrane lipids in all eukaryotes and are indispensable for eukaryotic life. First of all, the involvement of sphingolipids in organizing the lateral domain structure of membranes appears essential for processes like protein sorting and membrane signaling.
van Meer, G., Holthuis, J.C.M.
openaire   +4 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Alterations in mRNA and protein profiles in eIF4E-transfected human lung carcinoma cells [PDF]

, 2006
Previous work has shown that treatment of the lung cell carcinoma cell line DLKP with the differentiation modulating agent bromodeoxyuridine (BrdU) causes posttranscriptionally regulated changes in the expression of growth and differentiation related ...
Power, Brendan
core  

Modelling cell movement and chemotaxis pseudopod based feedback [PDF]

, 2011
A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of non-linear reaction-diffusion equations, is approximated on an evolving cell boundary using ...
Neilson, Matthew Paterson, Mackenzie, J.A., Webb, Steven, Mackenzie, John, R. H. Insall, J. A. Mackenzie, M. P. Neilson, S. D. Webb, Insall, Robert H., Webb, S.D., Neilson, M.P., Insall, R.H.   +11 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Zinc oxide nanoparticles as selective killers of proliferating cells [PDF]

, 2011
Background: It has recently been demonstrated that zinc oxide nanoparticles (ZnO NPs) induce death of cancerous cells whilst having no cytotoxic effect on normal cells.
Liuba Taccola, Vanacore, Renato, Maria Carla Iorio, Raffa, Vittoria, Taccola, L, Orazio Vittorio, Andrea Pietrabissa, Renato Vanacore, Cuschieri, Alfred, Iorio, Maria Carla, C. Riggio, Cuschieri, A., null Cristina Riggio, V. Raffa, Vanacore, R, Taccola, Liuba, Alfred Cuschieri, Vittorio, O, Pietrabissa, A, Pietrabissa, Andrea, O. Vittorio, Riggio, C, Vittoria Raffa, Iorio, Mc, Vittorio, Orazio, Riggio, Cristina, M.C. Iorio, R. Vanacore, A. Cuschieri   +28 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Identifying the role of Mer receptor tyrosine kinase in glioblastoma multiforme [PDF]

, 2012
GBM is one of the most aggressive human cancers. Primary GBM, which comprises more than 90% of biopsied or resected brain tumors, arises de novo without an antecedent history of low-grade disease.
Yuhua, Wang
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

What drove bacterial cells to adopt an intracellular lifestyle in eukaryotic cells during pathogenesis? [PDF]

, 2020
Many bacteria invade eukaryotic cells and grow within the larger host cells. This typically results in pathogenesis and an intracellular infection, often detrimental to the host cells.
Wenfa Ng (444092)
core   +1 more source