Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]
, 2011 Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel +66 more
core +14 more sources
Integrating Horizontal Gene Transfer and Common Descent to Depict Evolution and Contrast It with ‘‘Common Design [PDF]
, 2010 Horizontal gene transfer (HGT) and common descent interact in space and time. Because events of HGT co-occur with phylogenetic evolution, it is difficult to depict evolutionary patterns graphically. Tree-like representations of life’s diversification are
Espinosa, Avelina +1 more
core +2 more sources
The origin of eukaryotes: the difference between prokaryotic and eukaryotic cells [PDF]
Proceedings of the Royal Society of London. Series B: Biological Sciences, 1999 Eukaryotes have long been thought to have arisen by evolving a nucleus, endomembrane, and cytoskeleton. In contrast, it was recently proposed that the first complex cells, which were actually proto-eukaryotes, arose simultaneously with the acquisition of mitochondria.
T, Vellai, G, Vida
openaire +2 more sources
The basic principles of DNA damage detection by the alkaline comet assay [PDF]
Arhiv za farmacijuThe Comet assay is a highly sensitive and rapid method for detecting DNA damage at the level of individual cells. It measures single-stranded and double-stranded DNA breaks, alkali-labile, incomplete excision repair and cross-linking sites.
Živković Lada +6 more
doaj +1 more source
Quantitative single-molecule microscopy reveals that CENP-A(Cnp1) deposition occurs during G2 in fission yeast [PDF]
, 2012 The inheritance of the histone H3 variant CENP-A in nucleosomes at centromeres following DNA replication is mediated by an epigenetic mechanism. To understand the process of epigenetic inheritance, or propagation of histones and histone variants, as ...
Allshire, Robin C +11 more
core +3 more sources
Prokaryotic cells: structural organisation of the cytoskeleton and organelles
Memorias do Instituto Oswaldo Cruz, 2012 For many years, prokaryotic cells were distinguished from eukaryotic cells based on the simplicity of their cytoplasm, in which the presence of organelles and cytoskeletal structures had not been discovered.
Wanderley de Souza
doaj +1 more source
Output Regulation and Function Optimization of Mitochondria in Eukaryotes
Frontiers in Cell and Developmental Biology, 2020 The emergence of endosymbiosis between aerobic alpha-proteobacterium and anaerobic eukaryotic cell precursors opened the chapter of eukaryotic evolution.
Miaolin Zeng +5 more
doaj +1 more source
An in vivo control map for the eukaryotic mRNA translation machinery [PDF]
, 2013 Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway.
Amy Claydon +12 more
core +3 more sources
Translation inhibition by rocaglates is independent of eIF4E phosphorylation status [PDF]
, 2016 Rocaglates are natural products that inhibit protein synthesis in eukaryotes and exhibit antineoplastic activity. In vitro biochemical assays, affinity chromatography experiments coupled with mass spectrometry analysis, and in vivo genetic screens have ...
Cencic, Regina +4 more
core +1 more source
Free-living protozoa in two unchlorinated drinking water supplies identified by phylogenic analysis of 18S rRNA gene sequences [PDF]
, 2009 Free-living protozoan communities in water supplies may include hosts for Legionella pneumophila and other undesired bacteria and also pathogens. This study aimed at identifying free-living protozoa in two unchlorinated groundwater supplies using ...
Valster, R.M. +4 more
core +1 more source