Results 31 to 40 of about 206,173 (282)

DNA Copy-Number Control through Inhibition of Replication Fork Progression

Cell Reports, 2014
Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders.
Jared T. Nordman, Elena N. Kozhevnikova, C. Peter Verrijzer, Alexey V. Pindyurin, Evgeniya N. Andreyeva, Victor V. Shloma, Igor F. Zhimulev, Terry L. Orr-Weaver   +7 more
doaj   +1 more source

Molecular dissection of the domain architecture and catalytic activities of human PrimPol [PDF]

, 2014
PrimPol is a primase–polymerase involved in nuclear and mitochondrial DNA replication in eukaryotic cells. Although PrimPol is predicted to possess an archaeo-eukaryotic primase and a UL52-like zinc finger domain, the role of these domains has not been ...
Aidan J. Doherty, Aravind, Benjamin A. Keen, Bianchi, Biertümpfel, Biswas, Bocquier, Boudsocq, Brautigam, Chen, Chen, Connolly, Corn, Della, Duncan, Engelke, Fogg, Frick, Garcia-Gomez, Graziewicz, Griep, Hays, Iyer, Johnson, Julie Bianchi, Kim, Lao-Sirieix, Lao-Sirieix, Laura J. Bailey, Lehmann, Lipps, Liu, Maga, Masutani, Mendelman, Ohashi, Pelletier, Pinz, Pitcher, Rudd, Shannon, Stanislaw K. Jozwiakowski, Tabor, van Loon, Wan, Washington   +45 more
core   +2 more sources

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa, A Fernández-Cid, Alberto Riera, Alejandra Fernández-Cid, AS Brewster, AY Lyubimov, B Stillman, BA Kelch, BI Khayrutdinov, Bruce Stillman, C Evrin, C Evrin, C Liu, C Santocanale, C Speck, C Speck, Cecile Evrin, Christian Speck, D Remus, D Remus, D Suck, E Arias-Palomo, EF Pettersen, EL Dueber, G Tang, GC Lander, GD Bowman, GD Pintilie, H Li, H Li, Hironori Kawakami, Huilin Li, I Ilves, IN Chesnokov, J Frigola, J Liu, J Sun, JC Randell, Jingchuan Sun, JL Bowers, L Zou, M Gaudier, M O'Donnell, MG Clarey, MG Clarey, ML Baker, ML Bochman, ML Bochman, ML Bochman, PW Lau, R Henderson, RC Heller, RD Klemm, RJ Fletcher, S Chen, S Donovan, S Onesti, S Waga, SE Moyer, SL Forsburg, SP Bell, SP Bell, Stefan A Samel, T Miyata, T Pape, Y Ishimi, Y Kawasaki, YH Kang, Z Chen   +68 more
core   +1 more source

Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1

BMC Genetics, 2007
Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes.
DasSarma Shiladitya, DasSarma Priya, Berquist Brian R   +2 more
doaj   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major

Cell Reports, 2016
Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how origins are specified and selected for activation varies across different
Rodrigo Lombraña, Alba Álvarez, José Miguel Fernández-Justel, Ricardo Almeida, César Poza-Carrión, Fábia Gomes, Arturo Calzada, José María Requena, María Gómez   +8 more
doaj   +1 more source

Orchestrated transcription of biological processes in the marine picoeukaryote Ostreococcus exposed to light/dark cycles [PDF]

, 2010
Background: Picoeukaryotes represent an important, yet poorly characterized component of marine phytoplankton. The recent genome availability for two species of Ostreococcus and Micromonas has led to the emergence of picophytoplankton comparative ...
Bouget, François-Yves, Bouvet, Régis, Corellou, Florence, Jesson, Béline, Liverani, Silvia, Monnier, Annabelle, Mosser, Jean, Smith, J. Q.   +7 more
core   +7 more sources

DNA Sliding Clamps as Therapeutic Targets

Frontiers in Molecular Biosciences, 2018
Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA
Amanda S. Altieri, Zvi Kelman, Zvi Kelman   +2 more
doaj   +1 more source

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz, Corey Nislow, Grant W Brown   +2 more
doaj   +1 more source

Transcriptome changes and cAMP oscillations in an archaeal cell cycle [PDF]

, 2007
Background The cell cycle of all organisms includes mass increase by a factor of two, replication of the genetic material, segregation of the genome to different parts of the cell, and cell division into two daughter cells.
Baumann, Anke, Lange, Christian, Soppa, Jörg (Prof. Dr.)   +2 more
core   +3 more sources