Results 11 to 20 of about 204,342 (301)
Processing ribonucleotides incorporated during eukaryotic DNA replication. [PDF]
Nat Rev Mol Cell Biol, 2016 Williams JS, Lujan SA, Kunkel TA.
europepmc +2 more sources
Regulated eukaryotic DNA replication origin firing with purified proteins. [PDF]
Nature, 2015 Yeeles JT +4 more
europepmc +2 more sources
, 2019 Maintenance of genome integrity is a key process in all organisms. DNA polymerases (Pols) are central players in this process as they are in charge of the faithful reproduction of the genetic information, as well as of DNA repair.
De Veylder, Lieven +2 more
core +3 more sources
Affinity Purification of an Archaeal DNA Replication Protein Network
mBio, 2010 Nineteen Thermococcus kodakarensis strains have been constructed, each of which synthesizes a different His6-tagged protein known or predicted to be a component of the archaeal DNA replication machinery.
Zhuo Li +4 more
doaj +1 more source
Coupling DNA Replication and Spindle Function in Saccharomyces cerevisiae
Cells, 2021 In the yeast Saccharomyces cerevisiae DNA replication and spindle assembly can overlap. Therefore, signaling mechanisms modulate spindle dynamics in order to ensure correct timing of chromosome segregation relative to genome duplication, especially when ...
Dimitris Liakopoulos
doaj +1 more source
Proficient replication of the yeast genome by a viral DNA polymerase [PDF]
, 2016 DNA replication in eukaryotic cells requires minimally three B-family DNA polymerases: Pol α, Pol δ, and Pol ϵ. Pol δ replicates and matures Okazaki fragments on the lagging strand of the replication fork.
Burgers, Peter M +2 more
core +2 more sources
Molecular dissection of the domain architecture and catalytic activities of human PrimPol [PDF]
, 2014 PrimPol is a primase–polymerase involved in nuclear and mitochondrial DNA replication in eukaryotic cells. Although PrimPol is predicted to possess an archaeo-eukaryotic primase and a UL52-like zinc finger domain, the role of these domains has not been ...
Aidan J. Doherty +45 more
core +2 more sources
3 tera-basepairs as a fundamental limit for robust DNA replication [PDF]
, 2020 10 p.-2 tab.In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly ...
Al Mamun, M. +3 more
core +3 more sources
Replicating Damaged DNA in Eukaryotes [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 DNA damage is one of many possible perturbations that challenge the mechanisms that preserve genetic stability during the copying of the eukaryotic genome in S phase. This short review provides, in the first part, a general introduction to the topic and an overview of checkpoint responses.
Nimrat, Chatterjee, Wolfram, Siede
openaire +2 more sources
PLoS ONE, 2012 DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe +7 more
doaj +1 more source