Results 31 to 40 of about 204,342 (301)

Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]

, 2010
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G, Jonsson, Zophonias O, Lopez-Mosqueda, Jaime, Maas, Nancy L, Toczyski, David P, Wohlschlegel, James   +5 more
core   +2 more sources

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa, A Fernández-Cid, Alberto Riera, Alejandra Fernández-Cid, AS Brewster, AY Lyubimov, B Stillman, BA Kelch, BI Khayrutdinov, Bruce Stillman, C Evrin, C Evrin, C Liu, C Santocanale, C Speck, C Speck, Cecile Evrin, Christian Speck, D Remus, D Remus, D Suck, E Arias-Palomo, EF Pettersen, EL Dueber, G Tang, GC Lander, GD Bowman, GD Pintilie, H Li, H Li, Hironori Kawakami, Huilin Li, I Ilves, IN Chesnokov, J Frigola, J Liu, J Sun, JC Randell, Jingchuan Sun, JL Bowers, L Zou, M Gaudier, M O'Donnell, MG Clarey, MG Clarey, ML Baker, ML Bochman, ML Bochman, ML Bochman, PW Lau, R Henderson, RC Heller, RD Klemm, RJ Fletcher, S Chen, S Donovan, S Onesti, S Waga, SE Moyer, SL Forsburg, SP Bell, SP Bell, Stefan A Samel, T Miyata, T Pape, Y Ishimi, Y Kawasaki, YH Kang, Z Chen   +68 more
core   +1 more source

Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe [PDF]

, 2015
Background DNA replication initiates on defined genome sites, termed origins. Origin usage appears to follow common rules in the eukaryotic organisms examined to date: all chromosomes are replicated from multiple origins, which display variations in ...
Campbell, Samantha J., Dickens, Nicholas J., Marques, Catarina A., McCulloch, Richard, Paape, Daniel   +4 more
core   +2 more sources

DNA Copy-Number Control through Inhibition of Replication Fork Progression

Cell Reports, 2014
Proper control of DNA replication is essential to ensure faithful transmission of genetic material and prevent chromosomal aberrations that can drive cancer progression and developmental disorders.
Jared T. Nordman, Elena N. Kozhevnikova, C. Peter Verrijzer, Alexey V. Pindyurin, Evgeniya N. Andreyeva, Victor V. Shloma, Igor F. Zhimulev, Terry L. Orr-Weaver   +7 more
doaj   +1 more source

Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase

Nature Communications, 2022
The Dbf4-dependent kinase Cdc7 (DDK) is essential for eukaryotic DNA replication. Here, the authors present a series of cryo-EM structures elucidating the versatility of this kinase in exerting an ordered phosphorylation of its essential target to ...
Jiaxuan Cheng, Ningning Li, Yunjing Huo, Shangyu Dang, Bik-Kwoon Tye, Ning Gao, Yuanliang Zhai   +6 more
doaj   +1 more source

Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1

BMC Genetics, 2007
Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes.
DasSarma Shiladitya, DasSarma Priya, Berquist Brian R   +2 more
doaj   +1 more source

Transcriptionally Driven DNA Replication Program of the Human Parasite Leishmania major

Cell Reports, 2016
Faithful inheritance of eukaryotic genomes requires the orchestrated activation of multiple DNA replication origins (ORIs). Although origin firing is mechanistically conserved, how origins are specified and selected for activation varies across different
Rodrigo Lombraña, Alba Álvarez, José Miguel Fernández-Justel, Ricardo Almeida, César Poza-Carrión, Fábia Gomes, Arturo Calzada, José María Requena, María Gómez   +8 more
doaj   +1 more source

DNA Sliding Clamps as Therapeutic Targets

Frontiers in Molecular Biosciences, 2018
Chromosomal DNA replication is achieved by an assembly of multi-protein complexes at the replication fork. DNA sliding clamps play an important role in this assembly and are essential for cell viability. Inhibitors of bacterial (β-clamp) and eukaryal DNA
Amanda S. Altieri, Zvi Kelman, Zvi Kelman   +2 more
doaj   +1 more source

Reconstitution of recombination-associated DNA synthesis with human proteins. [PDF]

, 2013
The repair of DNA breaks by homologous recombination is a high-fidelity process, necessary for the maintenance of genome integrity. Thus, DNA synthesis associated with recombinational repair must be largely error-free.
Grossi, Sara M, Heyer, Wolf-Dietrich, Hurwitz, Jerard, Sneeden, Jessica L, Tappin, Inger   +4 more
core   +1 more source

Control of DNA Replication Initiation by Ubiquitin

Cells, 2018
Eukaryotic cells divide by accomplishing a program of events in which the replication of the genome is a fundamental part. To ensure all cells have an accurate copy of the genome, DNA replication occurs only once per cell cycle and is controlled by ...
Esperanza Hernández-Carralero, Elisa Cabrera, Ignacio Alonso-de Vega, Santiago Hernández-Pérez, Veronique A. J. Smits, Raimundo Freire   +5 more
doaj   +1 more source