Cell-cycle regulated transcription associates with DNA replication timing in yeast and human [PDF]
, 2013 Eukaryotic DNA replication follows a specific temporal program, with some genomic regions consistently replicating earlier than others, yet what determines this program is largely unknown.
Fraser, Hunter B.
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Cell Reports, 2019 Summary: Progression of DNA replication depends on the ability of the replisome complex to overcome nucleoprotein barriers. During eukaryotic replication, the CMG helicase translocates along the leading-strand template and unwinds the DNA double helix ...
Hazal B. Kose +3 more
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Ancient diversification of eukaryotic MCM DNA replication proteins
BMC Evolutionary Biology, 2009 Background Yeast and animal cells require six mini-chromosome maintenance proteins (Mcm2-7) for pre-replication complex formation, DNA replication initiation and DNA synthesis. These six individual MCM proteins form distinct heterogeneous subunits within
Aves Stephen J +2 more
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TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
Nature Communications, 2020 Eukaryotic topoisomerase 1 (TOP1) regulates DNA topology to ensure efficient DNA replication and transcription. Here, the authors reveal insights into the molecular resolution of topoisomerase 1-DNA adducts by TEX264, p97 and SPRTN.
John Fielden +16 more
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Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation [PDF]
, 2016 Initiation of DNA replication depends upon recognition of genomic sites, termed origins, by AAA+ ATPases. In prokaryotes a single factor binds each origin, whereas in eukaryotes this role is played by a six-protein origin recognition complex (ORC).
Damasceno, Jeziel D. +7 more
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Role for RNA: DNA hybrids in origin-independent replication priming in a eukaryotic system [PDF]
, 2015 DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset of DNA synthesis mediated by ...
Aguilera López, Andrés +3 more
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Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression
Molecular Systems Biology, 2009 This report provides a global view of how gene expression is affected by DNA replication. We analyzed synchronized cultures of Saccharomyces cerevisiae under conditions that prevent DNA replication initiation without delaying cell cycle progression.
Larsson Omberg +5 more
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Helicase Loading at Chromosomal Origins of Replication [PDF]
, 2013 Loading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of replication, the loaded helicase is required for the ...
Bell, Stephen P., Kaguni, Jon M.
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RETRACTED: The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA
eLife, 2016 DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin.
Dahai Gai +3 more
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Primase-polymerases are a functionally diverse superfamily of replication and repair enzymes [PDF]
, 2015 Until relatively recently, DNA primases were viewed simply as a class of proteins that synthesize short RNA primers requisite for the initiation of DNA replication.
Aidan J. Doherty +17 more
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