Results 31 to 40 of about 173,490 (195)

Genome-wide CRISPR screens identify noncanonical translation factor eIF2A as an enhancer of SARS-CoV-2 programmed −1 ribosomal frameshifting

Cell Reports, 2023
Summary: Many positive-strand RNA viruses, including all known coronaviruses, employ programmed −1 ribosomal frameshifting (−1 PRF) to regulate the translation of polycistronic viral RNAs.
Lian-Huan Wei, Yu Sun, Junjie U. Guo
doaj   +1 more source

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.

Journal of Biological Chemistry, 1987
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF-2) is a major mechanism regulating protein synthesis in rabbit reticulocytes.
Kathleen A. ScorsoneS, R. Panniers, Anne, Rowlands, Edgar, Henshaw   +5 more
semanticscholar   +1 more source

Upregulation of a novel eukaryotic translation initiation factor 5A (eIF5A) in dengue 2 virus-infected mosquito cells

Virology Journal, 2010
Background Dengue virus, a mosquito-borne flavivirus, is the etiological agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It generally induces apoptosis in mammalian cells, but frequently results in persistent infection in ...
Shih Yu-Tzu, Yang Chao-Fu, Chen Wei-June
doaj   +1 more source

Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells

Scientific Reports, 2021
The eukaryotic elongation factor-2 kinase, eEF2K, which restricts protein translation elongation, has been identified as a potential therapeutic target for diverse types of malignancies including triple negative breast cancer (TNBC).
YoungJun Ju, Yaacov Ben-David, Daniela Rotin, Eldad Zacksenhaus   +3 more
doaj   +1 more source

OseIF3h Regulates Plant Growth and Pollen Development at Translational Level Presumably through Interaction with OsMTA2

Plants, 2021
The initiation stage of protein biosynthesis is a sophisticated process tightly regulated by numerous initiation factors and their associated components. However, the mechanism underlying translation initiation has not been completely understood in rice.
Yuqing Huang, Peng Zheng, Xuejiao Liu, Hao Chen, Jumin Tu   +4 more
doaj   +1 more source

Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling

Journal of Lipid Research, 2009
Glucosamine impairs hepatic apolipoprotein B100 (apoB100) production by inducing endoplasmic reticulum (ER) stress and enhancing cotranslational and posttranslational apoB100 degradation (Qiu, W., R. K. Avramoglu, A. C. Rutledge, J. Tsai, and K.
Wei Qiu, Qiaozhu Su, Angela C. Rutledge, Jing Zhang, Khosrow Adeli   +4 more
doaj   +1 more source

Phosphorylation of the α-Subunit of the Eukaryotic Initiation Factor-2 (eIF2α) Reduces Protein Synthesis and Enhances Apoptosis in Response to Proteasome Inhibition*

Journal of Biological Chemistry, 2005
Protein ubiquitination and subsequent degradation by the proteasome are important mechanisms regulating cell cycle, growth and differentiation, and apoptosis.
Hao Jiang, R. Wek
semanticscholar   +1 more source

Reactivity of vertebrate-directed phospho-eEF2 antibody against the Caenorhabditis elegans orthologue phospho-EEF-2 [version 1; referees: 2 approved]

F1000Research, 2015
Eukaryotic protein translation is divided into three mains stages: initiation, elongation and termination. Regulation of this process occurs at the initiation and elongation step.
Viviane Alves
doaj   +1 more source

Unanticipated antigens: translation initiation at CUG with leucine.

PLoS Biology, 2004
Major histocompatibility class I molecules display tens of thousands of peptides on the cell surface for immune surveillance by T cells. The peptide repertoire represents virtually all cellular translation products, and can thus reveal a foreign presence
Susan R Schwab, Jessica A Shugart, Tiffany Horng, Subramaniam Malarkannan, Nilabh Shastri   +4 more
doaj   +1 more source

Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs

Life Science Alliance, 2020
This study highlights the role of transglutaminase 2 in selective mRNA translation of hypoxic cancer cells by polyamination-dependent modulation of 4EBPs, providing a target for cancer treatment.
Sung-Yup Cho, Seungun Lee, Jeonghun Yeom, Hyo-Jun Kim, Jin-Haeng Lee, Ji-Woong Shin, Mee-ae Kwon, Ki Baek Lee, Eui Man Jeong, Hee Sung Ahn, Dong-Myung Shin, Kyunggon Kim, In-Gyu Kim   +12 more
doaj   +1 more source