Results 41 to 50 of about 173,490 (195)

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation

Data in Brief, 2017
The data described in this article are related to “High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans” (Manfrini et ...
Nicola Manfrini, Sara Ricciardi, Annarita Miluzio, Maya Fedeli, Alessandra Scagliola, Simone Gallo, Thure Adler, Dirk H. Busch, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Stefano Biffo   +11 more
doaj   +1 more source

Heme-regulated Inhibitor Kinase-mediated Phosphorylation of Eukaryotic Translation Initiation Factor 2 Inhibits Translation, Induces Stress Granule Formation, and Mediates Survival upon Arsenite Exposure*

Journal of Biological Chemistry, 2005
Exposure to arsenite inhibits protein synthesis and activates multiple stress signaling pathways. Although arsenite has diverse effects on cell metabolism, we demonstrated that phosphorylation of eukaryotic translation initiation factor 2 at Ser-51 on ...
E. McEwen, N. Kedersha, B. Song, D. Scheuner, Natalie Gilks, A. Han, Jane-Jane Chen, P. Anderson, R. Kaufman   +8 more
semanticscholar   +1 more source

Early postnatal alterations in follicular stress response and survival in a mouse model of Classic Galactosemia

Journal of Ovarian Research, 2022
Primary ovarian insufficiency is characterized by accelerated loss of primordial follicles, which results in ovarian failure and concomitant menopause before age 40. About 1–3% of females in the general population are diagnosed with POI; however, greater
Synneva Hagen-Lillevik, Joshua Johnson, Kent Lai   +2 more
doaj   +1 more source

A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response

Frontiers in Molecular Neuroscience, 2023
ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex ...
Graham Neill, Glenn R. Masson
doaj   +1 more source

RT-qPCR normalization genes in the red alga Chondrus crispus. [PDF]

PLoS ONE, 2014
Chondrus crispus is a common red macroalga living on the rocky shores of the North Atlantic Ocean. It has a long research history, being a major source of carrageenan, a thickener widely used in the food industry, but also for physiological and ...
Nathalie Kowalczyk, Sylvie Rousvoal, Cécile Hervé, Catherine Boyen, Jonas Collén   +4 more
doaj   +1 more source

EIF2Ss, a Novel c-Myc-Correlated Gene Family, is Associated with Poor Prognosis and Immune Infiltration in Pancreatic Adenocarcinoma

Frontiers in Bioscience-Landmark
Background: Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor in urgent need of novel diagnostics, prognostic markers, and treatments. Eukaryotic translation initiation factor 2 subunits (EIF2Ss), comprising Eukaryotic translation initiation ...
Zhangqi Cao, Yanhua Jing, Chienshan Cheng, Fengjiao Wang, Mingwei Guan, Ke Zhang, Juying Jiao, Linjie Ruan, Zhen Chen   +8 more
doaj   +1 more source

ABC50 Interacts with Eukaryotic Initiation Factor 2 and Associates with the Ribosome in an ATP-dependent Manner*

Journal of Biological Chemistry, 2000
Eukaryotic initiation factor 2 (eIF2) plays a key role in the process of translation initiation and in its control. Here we demonstrate that highly purified mammalian eIF2 contains an additional polypeptide of apparent molecular mass of 110 kDa.
J. Tyzack, Xuemin Wang, G. Belsham, C. Proud   +3 more
semanticscholar   +1 more source

Rapamycin inhibits IGF-1-mediated up-regulation of MDM2 and sensitizes cancer cells to chemotherapy.

PLoS ONE, 2013
The Murine Double Minute 2 (MDM2) protein is a key regulator of cell proliferation and apoptosis that acts primarily by inhibiting the p53 tumor suppressor. Similarly, the PI3-Kinase (PI3K)/AKT pathway is critical for growth factor-mediated cell survival.
Wei Du, Yong Yi, Haibo Zhang, Johann Bergholz, Junfeng Wu, Haoqiang Ying, Yujun Zhang, Zhi-Xiong Jim Xiao   +7 more
doaj   +1 more source

Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier

FEBS Letters, 2009
Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating
Schmitt, Emmanuelle, Naveau, Marie, Mechulam, Yves   +2 more
openaire   +3 more sources

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK [PDF]

The Journal of Cell Biology, 2006
Regulated phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α) by the endoplasmic reticulum (ER) stress-activated protein kinase PERK modulates protein synthesis and couples the production of ER client proteins with the organelle's capacity to fold and process them.
Marciniak, Stefan J, Garcia-Bonilla, Lidia, Hu, Junjie, Harding, Heather P, Ron, David   +4 more
openaire   +3 more sources