Results 131 to 140 of about 19,199 (198)

Closing the Translational Gap: Closed‐Loop AI Discovery Frameworks for Experimental Validation and Clinical Implementation in Cancer Therapeutics

Cancer Medicine, Volume 15, Issue 8, August 2026.
Artificial intelligence accelerates cancer therapeutic development through an iterative, closed‐loop pipeline: from AI‐driven target and drug discovery, through automated synthesis and screening, to experimental validation in in vivo tumor models, culminating in clinical translation guided by patient data.
Tuğba Ören Varol, Mehmet Varol
wiley   +1 more source

Identification and Validation of Metabolic Hub Genes Using WGCNA and Prognostic Risk Modeling in Acute Myeloid Leukemia

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Acute myeloid leukemia (AML) is an aggressive and molecularly heterogeneous hematologic malignancy associated with poor clinical outcomes, particularly in elderly and high‐risk patients. Increasing evidence suggests that metabolic reprogramming plays a critical role in leukemia progression, immune dysregulation, and therapeutic ...
Samaneh Ramezani, Fatemeh Akhoundi, Reza Valadan, Hossein Asgarian‐Omran   +3 more
wiley   +1 more source

Integrative multi‐omics analysis prioritizes DPEP1 as a genetically supported candidate associated with skin cancer risk

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Flowchart of the study design outlining target identification, validation, and subsequent functional and translational characterization. Abstract Background Skin cancer (SC) is among the most prevalent malignancies, yet causal circulating proteins and tractable therapeutic targets remain poorly defined.
Fan Shen, Yongkai Yu, Zongfeng Liao, Liye Mao, Qianyun Wang, Wanju Wang, Yuanhui Liu, Ling Li   +7 more
wiley   +1 more source

PolyGenie: a reproducible Nextflow pipeline for phenome-wide association studies using polygenic risk scores. [PDF]

NAR Genom Bioinform
Farré X, Gasco M, Blay N, de Cid R.
europepmc   +1 more source

Astrocytic mGluR5 Regulation of Synaptic Transmission is Activity‐Dependent in Adult Rats

Glia, Volume 74, Issue 8, August 2026.
In adulthood, astrocytic mGluR5 increases synaptic efficacy through presynaptic A2ARs. This occurs when a small number of synapses are activated simultaneously. This pathway is abolished when numerous synapses are recruited. ABSTRACT Data accumulated over the last two decades have demonstrated that astrocytes play key roles in the regulation of ...
Sarah Mountadem, Muna L. Hilal, Dylan Pommier, Dorian Arnouil, Valentin Clément Langlais, Vincent Simon, Aurélie Amadio, Marie Miegebielle, Sébastien Marais, Charlène Joséphine, Astrid Cannich, Marjorie Varilh, Julien Bourel, Daniela Cota, Giovanni Marsicano, Alexis‐Pierre Bemelmans, Philippe Ciofi, Stéphane Henri Richard Oliet, Aude Panatier   +18 more
wiley   +1 more source

Single-cell and spatial transcriptomics in Phragmites australis reveal the association of B chromosomes with plant invasiveness. [PDF]

Genome Biol
Wang C, Ord J, Yan M, Cai Y, Shao H, Lin L, Salojärvi J, Liu L, Guo W.   +8 more
europepmc   +1 more source

The Relationship Between Polygenic Risk of Depression and Regional Brain Atrophy in Older Adults

International Journal of Geriatric Psychiatry, Volume 41, Issue 8, August 2026.
ABSTRACT Background Depression has been identified as a risk factor for the development of dementia, but the relationship between the two conditions is complex. If the mechanism by which depression increased the risk of dementia was better understood then new treatment targets could be identified.
Lindsey I. Sinclair, Clive G. Ballard, David A. Bennett, Jennifer C. Palmer, For the Alzheimer's Disease Neuroimaging Initiative, Sarah E. Medland   +5 more
wiley   +1 more source

The Brazilian Population Tumor Atlas Project: addressing representation in cancer genomics in Brazil. [PDF]

Lancet Reg Health Am
Boroni M, Costa Conteville L, Ribeiro Pinto LF, P B Viola J.   +3 more
europepmc   +1 more source

Diagnostic accuracy of phosphatase and tensin homolog loss in differentiating between atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia and non‐atypical endometrial hyperplasia: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, Volume 174, Issue 2, Page 630-642, August 2026.
Abstract Background Accurate distinction between atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (AH/EIN) and non‐atypical endometrial hyperplasia (EH) determines whether patients require hysterectomy or can be managed conservatively.
Kristina Shcherbatiuk, Steffi Bultmann, Thomas Karn, Khayal Gasimli, Peter Wild, Sven Becker, Morva Tahmasbi Rad   +6 more
wiley   +1 more source

LepEU: A Consortium to Study the Population Genomics of Butterflies and Moths Across Europe. [PDF]

Evol Appl
Beldade P, Vila M, Arif S, Bourgois A, Bridle J, Després L, Elias M, Espeland M, Fric ZF, Matos-Maraví P, Nam K, Poloni R, Repullés M, Saastamoinen M, Steward RA, Tunström K, Ulaşli B, Valentino T, Weinhold A, Wiemers M, Bailey RI, Blaxter M, Dincă V, Lucek K, Meier JI, Nielsen ME, Stefanescu C, Wright CJ, LepEU Community, Joron M, Wheat CW.   +30 more
europepmc   +1 more source