Results 111 to 120 of about 19,199 (198)

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer

The Journal of Pathology, Volume 270, Issue 1, Page 55-68, September 2026.
Abstract Recently, we suggested the combination of chemotherapy and P2RX4 inhibition as a promising novel therapeutic approach for P2RX4‐expressing epithelial tumors to prevent paracrine resistance. Here, we aimed to assess whether determining P2RX4 expression status in colorectal and pancreatic cancer patients would allow stratification of potentially
Christoph Steup, Julian Dosch, Christopher Dietz‐Fricke, Sara Khosraviseftejani, Esther Engel, Adalbert F de Valk, Dominic Menger, Patrick Welker, Peter J Wild, Kilian B Kennel, Maja Kantlehner, Paul K Ziegler, Florian R Greten   +12 more
wiley   +1 more source

Investigating enzyme function by geometric matching of catalytic motifs

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The rapidly growing universe of predicted protein structures offers opportunities for data driven exploration but requires computationally scalable and interpretable tools. We developed a method to detect catalytic features in protein structures, providing insights into enzyme function and mechanism.
Raymund E. Hackett, Ioannis G. Riziotis, Martin Larralde, António J. M. Ribeiro, Georg Zeller, Janet M. Thornton   +5 more
wiley   +1 more source

SorghumBase: a knowledgebase for sorghum genomics, phenomics, and stakeholder engagement. [PDF]

Genetics
Gladman N, Olson A, Kumari S, Wei S, Chougule K, Lu Z, Tello-Ruiz MK, Van Buren P, Kumar V, Zhang L, Olson A, Kim C, Braynen J, Hayes C, Xin Z, Klein R, Rooney W, Provart N, Pasha A, O'Meara A, Shakoor N, Michael TP, Harrison M, Ware D.   +23 more
europepmc   +1 more source

Nitrogen‐Starved Wheat: A Multi‐Omics Perspective From Epigenome Regulation to Grain Quality

Journal of Sustainable Agriculture and Environment, Volume 5, Issue 3, September 2026.
This review establishes epigenetic regulation, specifically H3K27ac and H3K27me3 dynamics at nitrogen transporter, assimilation, and storage protein loci, as a principal determinant of cultivar‐specific nitrogen use efficiency in hexaploid wheat, independent of DNA sequence variation, and identifies the rhizosphere microbiome as an integral but ...
Baber Ali, Zeeshan Khan, Nijat Imin
wiley   +1 more source

Expression Atlas in 2026: enabling FAIR and open expression data through community collaboration and integration. [PDF]

Nucleic Acids Res
Madrigal P, Thanki AS, Fexova S, Yu ID, Chatzigeorgiou A, Zucchi I, Marugan Calles JC, Vilmovsky L, Khen A, Zhao L, Erdos K, Kurri SR, Selvakumar S, Kumbham U, Prakash A, Wang S, Green A, Ribas CE, Sweeney B, Alegbe T, Suveges D, Hemrom A, Gomez Gutierrez DE, Insua S, Jeffryes M, Pearce M, Basutkar P, Kaforou M, Cunnington A, Levin M, Kumari S, Ware D, Goutte-Gattat D, Röper K, Brown NH, Hu Y, Perrimon N, Papatheodorou I, Brazma A, Hermjakob H, Harrison M, Ocaña D, Ochoa D, McDonagh EM, Bateman A, Keane T, Vizcaíno JA, Ernst C.   +47 more
europepmc   +1 more source

Neurodevelopmental Phenotypes and Brain Anomalies in Individuals With Heterozygous SEMA6A Variants

Clinical Genetics, Volume 110, Issue 3, Page 325-335, September 2026.
SEMA6A plays a role in cell migration and axon guidance in the developing central nervous system. Phenotypes seen in eleven individuals heterozygous for SEMA6A variants included developmental delay, intellectual disability, autism/autistic behaviors, behavioral abnormalities, attention disorders, hypotonia, and brain anomalies.
Evan Burchfiel, Xiaonan Zhao, Nichole M. Owen, Tia Gordon, Mahshid S. Azamian, Eric C. Kao, Fan Xia, Xi Luo, Jill A. Rosenfeld, Seema R. Lalani, Allison P. Ortega, Steven B. Bleyl, Florence Petit, Sulekha Rajagopolan, Bénédicte Demeer, Meredith K. Gillespie, Lijia Huang, Matthew Osmond, Kym M. Boycott, Kyra E. Stuurman, Marjon A. van Slegtenhorst, Haley Soller, Céline Jost, Aurore Garde, Hana Safraou, Laurence Faivre, Victor Faundes, Daryl A. Scott   +27 more
wiley   +1 more source

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source

Services for Patients with Rare Genetic Diseases in Germany. [PDF]

J Community Genet
Schmidtke C, Kühnen P, Mai K, Mundlos C, Cepus JS, Heider N, Lipp T.   +6 more
europepmc   +1 more source

An Update on Advancement in Genomics Resources for Spiny Lobster Aquaculture Development

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT The rapid advancement of high‐throughput sequencing technologies has transformed aquaculture genomics, enabling unprecedented insights into the biology and improvement of non‐model aquatic species. Among crustaceans, lobsters represent one of the most commercially valuable yet genomically underexplored taxa. This review synthesises the current
Courtney Lewis, Ahmad Farhadi, Susan Glendinning, Thomas Banks, Tara Kelly, Andrew G. Jeffs, Sandra Infante Villamil, John Breen, Jennifer M. Cobcroft, Arya Vazirzadeh, Basseer M. Codabaccus, Chris G. Carter, Quinn P. Fitzgibbon, Gregory G. Smith, Tomer Ventura   +14 more
wiley   +1 more source

Trans-ethnic estimation and implications of genetic impact on continuous glycemic profiles. [PDF]

Cell Discov
Yu EY, Ren HY, Liang X, Xi Y, Shuai M, Miao Z, Xu F, Zhang K, Shen L, Xia H, Schram MT, van Greevenbroek M, de Galan BE, van der Kallen CJH, Linden DEJ, Blokland GAM, Arts ICW, Berendschot TTJM, Yan Y, Fu Y, Wesselius A, Chen Y, Zheng JS.   +22 more
europepmc   +1 more source