Results 91 to 100 of about 19,199 (198)

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

A Faroese perspective on decoding life for sustainable use of nature and protection of biodiversity

npj Biodiversity
Biodiversity is under pressure, mainly due to human activities and climate change. At the international policy level, it is now recognised that genetic diversity is an important part of biodiversity.
Svein-Ole Mikalsen, Jari í Hjøllum, Ian Salter, Anni Djurhuus, Sunnvør í Kongsstovu   +4 more
doaj   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

Structural variant landscape provides insights into genome organisation and domestication in European seabass

BMC Biology
Background Structural variants (SVs) are genetic polymorphisms including deletions, insertions, inversions, and duplications, with potential to influence traits through impacts on gene function and expression. SVs have not been widely utilized in genetic
Zexin Jiao, Robert Mukiibi, Manu Kumar Gundappa, Massimiliano Babbucci, James G. D. Prendergast, Diego Robledo, Luca Bargelloni, Daniel J. Macqueen   +7 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Building a Portuguese coalition for biodiversity genomics

npj Biodiversity
The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable ...
João P. Marques, Paulo C. Alves, Isabel R. Amorim, Ricardo J. Lopes, Monica Moura, Eugene Myers, Manuela Sim-sim, Carla Sousa-Santos, M. Judite Alves, Paulo A. V. Borges, Thomas Brown, Miguel Carneiro, Carlos Carrapato, Luís M. P. Ceríaco, Claúdio Ciofi, Luís P. da Silva, Genevieve Diedericks, Maria Angela Diroma, Liliana Farelo, Giulio Formenti, Fátima Gil, Miguel Grilo, Alessio Iannucci, Henrique G. Leitão, Cristina Máguas, Ann M. Mc Cartney, Sofia L. Mendes, João M. Moreno, Marco Morselli, Alice Mouton, Chiara Natali, Fernando Pereira, Rúben M. C. Rego, Roberto Resendes, Guilherme Roxo, Hannes Svardal, Helena Trindade, Sara Vicente, Sylke Winkler, Marcela Alvarenga, Andreia J. Amaral, Agostinho Antunes, Paula F. Campos, Adelino V. M. Canário, Rita Castilho, L. Filipe C. Castro, Angelica Crottini, Mónica V. Cunha, Gonçalo Espregueira Themudo, Pedro J. Esteves, Rui Faria, Carlos Rodríguez Fernandes, Jean-Baptiste Ledoux, Bruno Louro, Sara Magalhaes, Octávio S. Paulo, Gareth Pearson, João Pimenta, Francisco Pina-Martins, Teresa L. Santos, Ester Serrão, José Melo-Ferreira, Vítor C. Sousa   +62 more
doaj   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, EarlyView.
Loss of Mecp2 function is associated with Rett syndrome (RTT). MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear. Combining MALDI‐MSI with LCM–LC–MS/MS, we mapped histone proteoforms across the dentate gyrus, cornu ammonis, and cerebellum in two mouse models of RTT.
Frederike Schäfer, Giuseppina De Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, EarlyView.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

A comprehensive atlas of nuclear sequences of mitochondrial origin (NUMT) inserted into the pig genome

Genetics Selection Evolution
Background The integration of nuclear mitochondrial DNA (mtDNA) into the mammalian genomes is an ongoing, yet rare evolutionary process that produces nuclear sequences of mitochondrial origin (NUMT).
Matteo Bolner, Samuele Bovo, Mohamad Ballan, Giuseppina Schiavo, Valeria Taurisano, Anisa Ribani, Francesca Bertolini, Luca Fontanesi   +7 more
doaj   +1 more source

Prospects of multipurpose biomonitoring for fisheries assessment based on environmental nucleic acids

Journal of Fish Biology, EarlyView.
Abstract Methods using environmental nucleic acids have become highly effective for monitoring aquatic biodiversity, with an array of suitable use cases, including metrics for fisheries assessment. Traditional methods for assessing fish populations often rely on invasive techniques with limited spatial and temporal coverage.
Ana Ramón‐Laca, Krista M. Nichols, Kim M. Parsons, Ramón Gallego, David R. Vieites, Ignacio Doadrio, Ana Riesgo   +6 more
wiley   +1 more source