Results 31 to 40 of about 19,199 (198)

ERGA-BGE reference genome of Hirudo verbana, a once neglected freshwater haematophagous European medicinal leech [version 1; peer review: 2 approved]

Open Research Europe
Hirudo verbana Carena, 1820, commonly known as the southern medicinal leech, is one of several European medicinal leeches, whose full diversity has just recently started to be uncovered.
Jonathan M.D. Wood, Shane McCarthy, Fergal Martin, Leanne Haggerty, Rebekah A. Oomen, Anna Lazar, Thomas Marcussen, Torsten H. Struck, Astrid Böhne, Chiara Bortoluzzi, Alejandro Manzano-Marín, Caroline Howard, Rita Monteiro, Mark Blaxter, Kerstin Howe   +14 more
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

ERGA-BGE reference genome of the Azores Bullfinch - Pyrrhula murina Godman, 1866: an IUCN Vulnerable Species endemic to a single island in the Azores Archipelago (Portugal) [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
The reference genome of Pyrrhula murina’s reference genome will substantially enhance the current monitoring of genetic diversity and population viability and will allow us to understand the effective population size trends throughout time and recent ...
Jèssica Gómez-Garrido, Fernando Cruz, Thomas Marcussen, Tyler S. Alioto, Astrid Böhne, Rita Monteiro, Ricardo Jorge Lopes, Marta Gut, Laura Aguilera, Torsten Hugo Struck, Francisco Câmara Ferreira, Rebekah A. Oomen   +11 more
doaj   +1 more source

A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance

Advanced Science, EarlyView.
Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng, Masaki Nasu, Ayman Abdul‐Ghani, Yu Chen, Shaoqiu Chen, Isam Mohd Ibrahim, Hanqiu Zhang, Lauren Higa, Zitong Gao, Hua Yang, Raphael Bueno, Loïc Le Marchand, Youping Deng   +12 more
wiley   +1 more source

ERGA-BGE reference genome of Hirudo verbana, a once neglected freshwater haematophagous European medicinal leech [version 2; peer review: 2 approved]

Open Research Europe
Hirudo verbana Carena, 1820, commonly known as the southern medicinal leech, is one of several European medicinal leeches, whose full diversity has just recently started to be uncovered.
Jonathan M.D. Wood, Shane McCarthy, Fergal Martin, Leanne Haggerty, Rebekah A. Oomen, Anna Lazar, Thomas Marcussen, Torsten H. Struck, Astrid Böhne, Chiara Bortoluzzi, Alejandro Manzano-Marín, Caroline Howard, Rita Monteiro, Mark Blaxter, Kerstin Howe   +14 more
doaj   +1 more source

Non-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan)

Genes and Environment, 2023
Aim Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to identify the difference of TP53 mutation
Hiroko Natsume, Kinga Szczepaniak, Hidetaka Yamada, Yuji Iwashita, Marta Gędek, Jelena Šuto, Keiko Ishino, Rika Kasajima, Tomonari Matsuda, Felix Manirakiza, Augustin Nzitakera, Yijia Wu, Nong Xiao, Qiong He, Wenwen Guo, Zhenming Cai, Tsutomu Ohta, Tıberiu Szekely, Zoltan Kadar, Akiko Sekiyama, Takashi Oshima, Takaki Yoshikawa, Akira Tsuburaya, Nobuhito Kurono, Yaping Wang, Yohei Miyagi, Simona Gurzu, Haruhiko Sugimura   +27 more
doaj   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

ERGA-BGE reference genome of the Eurasian Woodcock (Scolopax rusticola), a game bird species with isolated populations of conservation interest [version 1; peer review: 2 approved]

Open Research Europe
The reference genome of the Eurasian Woodcock (Scolopax rusticola) is an important resource to investigate population structure across the wide breeding range of this iconic game species and the conservation status of specific management units, such as ...
Torsten H. Struck, Rebekah A. Oomen, Diego Rubolini, Joan Ferrer Obiol, Francesco Giannelli, Josephine R. Paris, Pedro Andrade, David Gonçalves, Alessandro Tedeschi, Beneharo Rodríguez, Chiara Natali, Michele Sorrenti, Maria Angela Diroma, Marcella Sozzoni, Thomas Marcussen, Claudio Ciofi, Astrid Böhne, Chiara Bortoluzzi, Caroline Howard, Rita Monteiro, Mark Blaxter   +20 more
doaj   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source