Results 51 to 60 of about 19,199 (198)

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

ERGA-BGE reference genome of Eunicella cavolini, an IUCN Near Threatened Gorgonian of the Mediterranean Sea [version 2; peer review: 2 approved]

Open Research Europe
The Eunicella cavolini reference genome provides an important resource to study the adaptation of this species to different environments and anthropic pressures.
Patrick Wincker, Didier Aurelle, Denys Malengros, Corinne Cruaud, Dorian Guillemain, Frédéric Zuberer, Alice Moussy, Lola Demirdjian, Rebekah A. Oomen, Karine Labadie, Pedro H. Oliveira, Anne Lazar, Fergal Martin, Leanne Haggerty, Thomas Marcussen, Torsten H. Struck, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro, Caroline Belser   +20 more
doaj   +1 more source

Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes

Frontiers in Oncology, 2020
Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas
Enrico Melis, Enzo Gallo, Simona di Martino, Filippo Tommaso Gallina, Valentina Laquintana, Beatrice Casini, Paolo Visca, Federica Ganci, Gabriele Alessandrini, Mauro Caterino, Fabiana Letizia Cecere, Chiara Mandoj, Arianna Papadantonakis, Nicoletta De Bello, Rossano Lattanzio, Giovannella Palmieri, Marina Chiara Garassino, Nicolas Girard, Laura Conti, Giovanni Blandino, Francesco Fazi, Francesco Facciolo, Edoardo Pescarmona, Gennaro Ciliberto, Mirella Marino   +24 more
doaj   +1 more source

Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.
Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey   +23 more
wiley   +1 more source

ERGA-BGE reference genome of the lineid heteronemertean Lineus lacteus (Pilidiophora, Nemertea) [version 2; peer review: 2 approved]

Open Research Europe
The reference genome of Lineus lacteus is a crucial resource for studying the genetic basis of novelty and the evolution of remarkable traits, such as regeneration and venom, as well as the molecular mechanisms underlying adaptability in marine ...
Patricia Alvarez-Campos, Jèssica Gómez-Garrido, Aida Verdes, Fernando Cruz, Javier Palma-Guerrero, María Conejero, Ana Riesgo, Astrid Böhne, Chiara Bortoluzzi, Tyler S. Alioto, Rosa Fernández, Marta Gut, Laura Aguilera, Rita Monteiro, Francisco Câmara Ferreira   +14 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

ERGA-BGE reference genome of Lewinskya acuminata, a common epiphytic Mediterranean moss with disjunct populations in California and Ethiopia [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
The reference genome of Lewinskya acuminata (H. Philib.) F. Lara, Garilleti & Goffinet will enable phylogenomic, biogeographic, and evolutionary studies within the Orthotrichaceae and related bryophyte lineages at a depth previously inaccessible.
Francisco Lara, Pablo Aguado-Ramsay, Patrick Wincker, Maria Conejero, Isabel Draper, Corinne Cruaud, Torsten H. Struck, Alice Moussy, Lola Demirdjian, Rebekah A. Oomen, Karine Labadie, Emilie Téodori, Pedro H. Oliveira, Thomas Marcussen, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro   +17 more
doaj   +1 more source

Genomic Insights Into Spatiotemporal Dynamics of Acquired Azithromycin Resistance Genes in Salmonella Strains Worldwide

Food Safety and Health, EarlyView.
ABSTRACT Azithromycin has been used for clinical invasive infections caused by fluoroquinolone‐ and third‐generation cephalosporin‐resistant Salmonella, and mass drug administration with azithromycin has been used to reduce under‐5 mortality in children in some countries.
Yuhang Pei, Mengqi Qu, Ziru Yang, Xuebin Xu, Yanan Wang   +4 more
wiley   +1 more source

ERGA-BGE genome of Dendarus foraminosus: an IUCN Least Concern darkling beetle endemic to Crete (Greece) [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
Dendarus foraminosus Mulsant and Rey, 1855 is a darkling beetle in the family Tenebrionidae and one of the many Dendarus species endemic to the island of Crete. Dendarus foraminosus is a commonly found species and is widespread in the lowland and montane
Petros Lymberakis, Manos Stratakis, Fergal Martin, Nikolaos Poulakakis, Leanne Haggerty, Corinne Cruaud, Alice Moussy, Lola Demirdjian, Karine Labadie, Emilie Téodori, Simone Duprat, Pedro H. Oliveira, Patrick Wincker, Swati Sinha, Nuria Escudero, Rosa Fernández, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro, Danae Karakasi, Giannis Bolanakis, Eleftherios Bitzilekis, Apostolos Trichas   +23 more
doaj   +1 more source