Results 51 to 60 of about 19,340 (198)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

ERGA-BGE reference genome of the Azores Bullfinch - Pyrrhula murina Godman, 1866: an IUCN Vulnerable Species endemic to a single island in the Azores Archipelago (Portugal) [version 3; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
The reference genome of Pyrrhula murina’s reference genome will substantially enhance the current monitoring of genetic diversity and population viability and will allow us to understand the effective population size trends throughout time and recent ...
Jèssica Gómez-Garrido, Fernando Cruz, Thomas Marcussen, Tyler S. Alioto, Astrid Böhne, Rita Monteiro, Ricardo Jorge Lopes, Marta Gut, Laura Aguilera, Torsten Hugo Struck, Francisco Câmara Ferreira, Rebekah A. Oomen   +11 more
doaj   +1 more source

Thymic Epithelial Tumors as a Model of Networking: Development of a Synergistic Strategy for Clinical and Translational Research Purposes

Frontiers in Oncology, 2020
Among the group of thymic epithelial tumors (TET), thymomas often show either uncertain or explicit malignant biological behavior, local invasiveness, and intrathoracic relapse and are often difficult to manage. From the initial stages, thymic carcinomas
Enrico Melis, Enzo Gallo, Simona di Martino, Filippo Tommaso Gallina, Valentina Laquintana, Beatrice Casini, Paolo Visca, Federica Ganci, Gabriele Alessandrini, Mauro Caterino, Fabiana Letizia Cecere, Chiara Mandoj, Arianna Papadantonakis, Nicoletta De Bello, Rossano Lattanzio, Giovannella Palmieri, Marina Chiara Garassino, Nicolas Girard, Laura Conti, Giovanni Blandino, Francesco Fazi, Francesco Facciolo, Edoardo Pescarmona, Gennaro Ciliberto, Mirella Marino   +24 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

ERGA-BGE reference genome of Lewinskya acuminata, a common epiphytic Mediterranean moss with disjunct populations in California and Ethiopia [version 1; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
The reference genome of Lewinskya acuminata (H. Philib.) F. Lara, Garilleti & Goffinet will enable phylogenomic, biogeographic, and evolutionary studies within the Orthotrichaceae and related bryophyte lineages at a depth previously inaccessible.
Francisco Lara, Pablo Aguado-Ramsay, Patrick Wincker, Maria Conejero, Isabel Draper, Corinne Cruaud, Torsten H. Struck, Alice Moussy, Lola Demirdjian, Rebekah A. Oomen, Karine Labadie, Emilie Téodori, Pedro H. Oliveira, Thomas Marcussen, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro   +17 more
doaj   +1 more source

Common variation at 1q24.1 (ALDH9A1) is a potential risk factor for renal cancer.

PLoS ONE, 2015
So far six susceptibility loci for renal cell carcinoma (RCC) have been discovered by genome-wide association studies (GWAS). To identify additional RCC common risk loci, we performed a meta-analysis of published GWAS (totalling 2,215 cases and 8,566 ...
Marc Y R Henrion, Mark P Purdue, Ghislaine Scelo, Peter Broderick, Matthew Frampton, Alastair Ritchie, Angela Meade, Peng Li, James McKay, Mattias Johansson, Mark Lathrop, James Larkin, Nathaniel Rothman, Zhaoming Wang, Wong-Ho Chow, Victoria L Stevens, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Paul Brennan, Timothy Eisen, Stephen Chanock, Richard S Houlston   +22 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

ERGA-BGE genome of Dailognatha quadricollis, an East Mediterranean darkling beetle [version 2; peer review: 2 approved]

Open Research Europe
Dailognatha quadricollis (Coleoptera: Tenebrionidae) is a darkling beetle native to the Balkans and Eastern Mediterranean, with a range extending from Croatia to Lebanon.
Manos Stratakis, Nikos Poulakakis, Petros Lymberakis, Corinne Cruaud, Alice Moussy, Patrick Wincker, Lola Demirdjian, Karine Labadie, Emilie Téodori, Pedro H. Oliveira, Nuria Escudero, Rosa Fernández, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro, Danae Karakasi, Giannis Bolanakis, Eleftherios Bitzilekis, Apostolos Trichas   +19 more
doaj   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

ERGA-BGE reference genome of Lewinskya acuminata, a common epiphytic Mediterranean moss with disjunct populations in California and Ethiopia [version 2; peer review: 1 approved, 2 approved with reservations]

Open Research Europe
The reference genome of Lewinskya acuminata (H. Philib.) F. Lara, Garilleti & Goffinet will enable phylogenomic, biogeographic, and evolutionary studies within the Orthotrichaceae and related bryophyte lineages at a depth previously inaccessible.
Francisco Lara, Pablo Aguado-Ramsay, Patrick Wincker, Maria Conejero, Isabel Draper, Corinne Cruaud, Torsten H. Struck, Alice Moussy, Lola Demirdjian, Rebekah A. Oomen, Karine Labadie, Emilie Téodori, Pedro H. Oliveira, Thomas Marcussen, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro   +17 more
doaj   +1 more source