Results 41 to 50 of about 19,340 (198)
ERGA-BGE reference genome of Hirudo verbana, a once neglected freshwater haematophagous European medicinal leech [version 2; peer review: 2 approved]
Open Research EuropeHirudo verbana Carena, 1820, commonly known as the southern medicinal leech, is one of several European medicinal leeches, whose full diversity has just recently started to be uncovered.Jonathan M.D. Wood, Shane McCarthy, Fergal Martin, Leanne Haggerty, Rebekah A. Oomen, Anna Lazar, Thomas Marcussen, Torsten H. Struck, Astrid Böhne, Chiara Bortoluzzi, Alejandro Manzano-Marín, Caroline Howard, Rita Monteiro, Mark Blaxter, Kerstin Howe +14 moredoaj +1 more sourceGenome wide SNP discovery, analysis and evaluation in mallard (Anas platyrhynchos) [PDF]
, 2011 Background Next generation sequencing technologies allow to obtain at low cost the genomic sequence information that currently lacks for most economically and ecologically important organisms. For the mallard duck genomic data is limited. The mallard is, Kerstens Hindrik HD, van Hooft, W.F., van der Poel, J.J., Prins, Herbert HT, Robert HS Kraus, van Hooft, Pim, Kraus, R.H.S., Prins, Herbert H. T., Prins, H.H.T., Poel, J., Van Hooft Pim, Hooft, Pim Van, Li Ning, Jan J Van Der Poel, Johan Elmberg, Huang Yinhua, Prins Herbert HT, Elmberg, Johan, Vignal Alain, Martien AM Groenen, Crooijmans, Richard P. M. A., Elmberg Johan, Groenen, M.A.M., van Hooft, Pim,, Van Der Poel Jan J, Huang, Y., Kraus, Robert Hs, Pim Van Hooft, Vignal, Alain, Crooijmans, R.P.M.A., Yinhua Huang, Groenen, Martien A. M., Vignal, Alain,, Li, N., Crooijmans, R., Kerstens, H., Crooijmans, Richard P. M. A.,, Herbert HT Prins, Elmberg, J., Groenen, M., Kerstens, Hindrik HD, Elmberg, Johan,, Kraus, Robert, Groenen, Martien AM, Prins, Herbert H. T.,, Kraus Robert HS, Prins, H., Huang, Yinhua,, Groenen Martien AM, Poel, J.J., van der, Kersten, H.H.D., van der Poel, Jan J., Li, Ning, Kraus, Robert H. S.,, Kraus, Robert H. S., Huang, Yinhua, Hooft, W.F., van, Crooijmans, Richard PMA, Kerstens, Hindrik H. D.,, Kerstens, Hindrik H. D., Li, Ning,, Hooft, P., Hindrik HD Kerstens, Richard PMA Crooijmans, Vignal, A., Alain Vignal, Kraus, R., Groenen, Martien A. M.,, Ning Li, Crooijmans Richard PMA, van der Poel, Jan J., +70 morecore +1 more sourceSingle‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer
Advanced Science, EarlyView.Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang +10 morewiley +1 more sourceAdipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity
Advanced Science, EarlyView.Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker +22 morewiley +1 more sourceERGA-BGE reference genome of the Azores Bullfinch - Pyrrhula murina Godman, 1866: an IUCN Vulnerable Species endemic to a single island in the Azores Archipelago (Portugal) [version 2; peer review: 1 approved, 2 approved with reservations]
Open Research EuropeThe reference genome of Pyrrhula murina’s reference genome will substantially enhance the current monitoring of genetic diversity and population viability and will allow us to understand the effective population size trends throughout time and recent ...Jèssica Gómez-Garrido, Fernando Cruz, Thomas Marcussen, Tyler S. Alioto, Astrid Böhne, Rita Monteiro, Ricardo Jorge Lopes, Marta Gut, Laura Aguilera, Torsten Hugo Struck, Francisco Câmara Ferreira, Rebekah A. Oomen +11 moredoaj +1 more sourceERGA-BGE reference genome of Eunicella cavolini, an IUCN Near Threatened Gorgonian of the Mediterranean Sea [version 1; peer review: 2 approved]
Open Research EuropeThe Eunicella cavolini reference genome provides an important resource to study the adaptation of this species to different environments and anthropic pressures.Patrick Wincker, Didier Aurelle, Denys Malengros, Corinne Cruaud, Dorian Guillemain, Frédéric Zuberer, Alice Moussy, Lola Demirdjian, Rebekah A. Oomen, Karine Labadie, Pedro H. Oliveira, Thomas Marcussen, Torsten H. Struck, Astrid Böhne, Jean-Marc Aury, Chiara Bortoluzzi, Rita Monteiro, Caroline Belser +17 moredoaj +1 more sourceGenetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis
Annals of Neurology, EarlyView.Objective
Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud +5 morewiley +1 more sourceERGA-BGE reference genome of Hirudo verbana, a once neglected freshwater haematophagous European medicinal leech [version 1; peer review: 2 approved]
Open Research EuropeHirudo verbana Carena, 1820, commonly known as the southern medicinal leech, is one of several European medicinal leeches, whose full diversity has just recently started to be uncovered.Jonathan M.D. Wood, Shane McCarthy, Fergal Martin, Leanne Haggerty, Rebekah A. Oomen, Anna Lazar, Thomas Marcussen, Torsten H. Struck, Astrid Böhne, Chiara Bortoluzzi, Alejandro Manzano-Marín, Caroline Howard, Rita Monteiro, Mark Blaxter, Kerstin Howe +14 moredoaj +1 more sourceSheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis
Animal Research and One Health, EarlyView.Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan +10 morewiley +1 more sourceMulti‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis
Arthritis &Rheumatology, EarlyView.Objective
Systemic lupus erythematosus (SLE) is a multiorgan disease with widespread immune dysregulation and significant unmet clinical need. Blood‐based gene expression studies have advanced our understanding of SLE pathogenesis but may overlook critical tissue‐specific mechanisms that drive disease heterogeneity and progression.Michael A. Smith, Dominic Sinibaldi, Saifur Rahman, Chia‐Chien Chiang, Anna M. Hansen, Jill Henault, Carlos P. Roca, Shu Wang, Kamelia Zerrouki, Rebecca Filippi, Christopher Groves, Zerai Manna, Jun Chu, Michael Davis, Sarthak Gupta, Christopher Morehouse, Melissa de los Reyes, Rachel Ettinger, Roland Kolbeck, Mariana J. Kaplan, Miguel A. Sanjuan, Richard M. Siegel, Sarfaraz A. Hasni, Kerry A. Casey +23 morewiley +1 more source
