Results 151 to 160 of about 69,598 (254)

Neuregulin 4‐dependent MAPK amplification mediates urate‐induced β‐cell dysfunction

Journal of Diabetes Investigation, EarlyView.
Hyperuricemia impairs glucose homeostasis by inducing pancreatic β‐cell apoptosis without insulin resistance. In male Uox‐KO mice, urate upregulates Nrg4, which amplifies MAPK signaling and drives β‐cell death. Thus, hyperuricemia disrupts glucose metabolism via the Nrg4‐MAPK axis.
Yunyang Wang, Kun Zhang, Zhiyuan Li, Shuhui Hu, Yiru Zhang, Yulei Zhao, Xiaohan Liu, Jie Lu   +7 more
wiley   +1 more source

The Pseudomonas aeruginosa ribonuclease Ribocin cleaves eukaryotic ribosomes at helix 69 to inhibit host translation. [PDF]

PLoS Biol
Vasquez-Rifo A, Susorov D, Sholi EH, Demo G, Jami Y, Sha J, Wohlschlegel JA, Korostelev A, Ambros V.   +8 more
europepmc   +1 more source

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, EarlyView.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

Characterization of Leishmania infantum Isolates from Wild Leporids in the Community of Madrid (Spain). [PDF]

Vet Sci
Ortega-García MV, García N, Domínguez M, Moreno I.   +3 more
europepmc   +1 more source

Cytoarchitecture and myeloarchitecture of the sheep auditory cortex

Journal of Anatomy, EarlyView.
This article describes the cyto‐ and myeloarchitecture of the sheep auditory cortex. It outlines a six‐layered cortical organization, with variations in cellular types and densities. The potential location of the primary auditory cortex is indicated by parvalbumin immunostaining.
Camille Pluchot, Mélody Morisse, Maryse Meurisse, Jean‐Marie Graïc, Elodie Chaillou, Scott A. Love   +5 more
wiley   +1 more source

Species-specific dung characteristics and selective grazing jointly affect plant diversity in an experimental grassland community. [PDF]

Commun Biol
Sun X, Sitters J, Teixeira LH, Wassen MJ, Olde Venterink H.   +4 more
europepmc   +1 more source

Periodontitis and Adverse Pregnancy Outcomes: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This narrative review aims to describe mechanisms linking periodontal diseases in pregnancy with adverse pregnancy outcomes. ABSTRACT Periodontal diseases, including both gingivitis and periodontitis, occur commonly among pregnant individuals. Both gingivitis and periodontitis are associated with adverse pregnancy outcomes (APOs) such as early ...
Gregory C. Valentine, Yiorgos A. Bobetsis, Benjamin C. Shayo, Peter Milgrom, Phoebus N. Madianos   +4 more
wiley   +1 more source

A first case of <i>Hepatozoon</i> infection in a wild Amami rabbit (<i>Pentalagus furnessi</i>) in Tokunoshima Island, Japan. [PDF]

Int J Parasitol Parasites Wildl
Saito T, Noguchi H, Tokiwa T, Yoshimura H, Suzuki R, Torimoto R, Shiraishi T, Matsumoto K, Haritani M, Yamamoto M.   +9 more
europepmc   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages. [PDF]

EMBO Rep
Balka KR, Lamb OR, Venkatraman R, Magill Z, Hoang LT, Dumbrill R, McArthur K, de Weerd NA, Hertzog PJ, Crack PJ, Wakim LM, Good-Jacobson KL, Lahoud MH, O'Keeffe M, De Nardo D.   +14 more
europepmc   +1 more source