Effect of artificial warren size on a restocked European wild rabbit population
, 2017 C. Rouco was supported by a postdoctoral grant from the regional government of Castilla-La Mancha (JCCM) and the European Social Fund. Funding was provided by the projects by Confederacion Hidrografica del Guadalquivir, by the Projects CGL2005-02340/BOS, CGL2009-11665, FAU2006-0014-C-02-02, POII09-0099-2557 and PEII09-0097-436.
Rouco, Carlos +3 more
openaire +1 more source
The FEBS Journal, EarlyView.We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti +11 more
wiley +1 more source
Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice
The FEBS Journal, EarlyView.Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan +8 more
wiley +1 more source
The FEBS Journal, EarlyView.Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong +6 more
wiley +1 more source
Phosphorylation of BigH1 regulates its expression pattern and promotes embryonic development
The FEBS Journal, EarlyView.Phosphorylation is a key regulator of the linker histone variant BigH1 during Drosophila embryogenesis. We reveal that N‐terminal phosphorylation promotes the timely removal of BigH1 from chromatin. In contrast, C‐terminal phosphorylation supports early nuclear divisions and embryonic viability.
Ramóna Pék +9 more
wiley +1 more source
Effects of Experimental Infection with <i>Lagovirus europaeus</i> GI.1 and GI.2 on the Fecal Microbiota of Rabbits: New Insights into Virus-Host Microbiota Associations. [PDF]
Int J Mol SciHukowska-Szematowicz B +8 more
europepmc +1 more source
The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis
The FEBS Journal, EarlyView.H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo +8 more
wiley +1 more source
Beyond Genes: Metabolomic Evidence Indicates Potential Species-Level Differentiation in European Wild Rabbits. [PDF]
J Exp Zool A Ecol Integr PhysiolCortés-García C +8 more
europepmc +1 more source
SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC‐derived model
The FEBS Journal, EarlyView.In this study, we characterised the role of SHIP1 in regulating TREM2 signalling and global microglial myeloid functions using human‐induced pluripotent stem cell (hiPSC)‐derived macrophages. Knockout of SHIP1 (SHIP1 KO) in macrophages decreased inflammatory activation and levels of scavenger receptors. SHIP1 KO macrophages also exhibited reduced TREM2
Kim S. Martin +5 more
wiley +1 more source
EXO1 inhibition selectively kills replication repair-deficient cancer cells. [PDF]
NAR CancerMaric M, McClelland SE, Boulton SJ.
europepmc +1 more source