Results 171 to 180 of about 69,598 (254)

Catecholaminergic polymorphic ventricular tachycardia–linked ryanodine receptor variants exhibit domain‐specific calcium leak and calmodulin affinity properties

The Journal of Physiology, EarlyView.
Abstract figure legend Catecholaminergic polymorphic ventricular tachycardia (CPVT) variants in N terminal (NTD) and central domain (CD) but not pore domain induce a pathological RyR2 conformational shift upon protein kinase A (PKA) phosphorylation, similar to that seen in heart failure (HF), calcium/calmodulin‐dependent protein kinase II (CaMKII ...
Hitoshi Uchinoumi, Xiaoqiong Dong, Ivanita Stefanon, Yi Yang, Eduardo Hertel Ribeiro, Bengt Svensson, Xander H. T. Wehrens, Takeshi Yamamoto, Razvan L. Cornea, Robyn T. Rebbeck, Masafumi Yano, Donald M. Bers   +11 more
wiley   +1 more source

Sex Hormone-Binding Globulin Prevents Carbon Tetrachloride-Induced Liver Fibrosis Development. [PDF]

Int J Mol Sci
Álvarez-Guaita A, Briansó-Llort L, Cabrera-Serra J, Fuertes-Rioja L, Ramos-Pérez L, Salcedo-Allende MT, Hernández C, Simó R, Selva DM.   +8 more
europepmc   +1 more source

A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner, Fabio Frangiamore, Frédéric Sonak, Josef Madl, Thomas Seidel, Peter Kohl, Eva A. Rog‐Zielinska   +6 more
wiley   +1 more source

Loss of Gαq reshapes fibroblast traits and drives tumor-stroma remodeling in oral cancer progression. [PDF]

EMBO Rep
Navarro-Lérida I, Huertas-Lárez R, Paredes-García G, García-Mateos D, Jiménez-López MI, Prieto-Fernández L, Pascual A, Ávila-Oca V, López JA, Del Pozo MA, Álvarez-Teijeiro S, García-Pedrero JM, García-Escudero R, Mayor F, Ribas C.   +14 more
europepmc   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Voltage‐gated potassium channels mediate thyroid hormone control of skeletal muscle excitability

The Journal of Physiology, EarlyView.
Abstract figure legend Thyroid hormone (TH)‐dependent remodelling of potassium (K+) channel networks regulates skeletal muscle (SkM) excitability. Triiodothyronine (T3), locally generated from thyroxine (T4) by type 2 deiodinase (D2), binds thyroid hormone receptors (TRα/β) and modulates transcription via thyroid response elements (TREs).
Annarita Nappi, Caterina Miro, Annunziata Gaetana Cicatiello, Ilaria Piccialli, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Rosa Sirica, Melania Murolo, Emery Di Cicco, Daniela Terracciano, Anna Pannaccione, Monica Dentice   +12 more
wiley   +1 more source

Organization of Astrocytic GLT‐1 at Cortical Inhibitory Synapses

Glia, Volume 74, Issue 8, August 2026.
GLT‐1+ ALs frequently juxtapose symmetric synapses. Distance‐based phenotyping identifies symmetric‐ and asymmetric‐associated GLT‐1+ ALs. Distal inhibitory synapses show enriched GLT‐1/α2 couples in ALs within 1000 nm, conserved in human cortex. ABSTRACT Glutamate spillover from excitatory synapses modulates neighboring inhibitory synapses, yet the ...
Marcello Melone, Michael Di Palma, Annalisa Scimemi, Fiorenzo Conti   +3 more
wiley   +1 more source

Domestic European Rabbits <i>Oryctolagus cuniculus</i>: A Super-Highway for the Spread of Emergent Viral Diseases to Other Lagomorphs? [PDF]

Transbound Emerg Dis
Angulo E, Bárcena J, Cooke B, Soriguer RC.   +3 more
europepmc   +1 more source

Early Myelination Supports the Establishment of Consistent Handedness

Glia, Volume 74, Issue 7, July 2026.
Early compact myelin is essential for the establishment but not the maintenance of consistent paw preference in mice. Congenital myelin absence reduces lateralization and creates a leftward bias, underscoring a developmental role in shaping brain asymmetries. ABSTRACT Lateralization of brain functions, such as handedness, is thought to enhance cortical
Sharlen Moore, Swati Subramanian, Martin Meschkat, Jonas W. Hemesath, Torben Ruhwedel, Wiebke Möbius, Klaus‐Armin Nave, Livia de Hoz   +7 more
wiley   +1 more source

RUVBL1 and RUVBL2 are druggable MYC effector regulators in neuroblastoma cells. [PDF]

iScience
Siaw JT, Claeys A, Lai WY, Borenäs M, Hilgert E, Bekaert SL, Sanders E, Kaya I, Van Dorpe J, Speleman F, Durinck K, Hallberg B, Palmer RH, Van den Eynden J.   +13 more
europepmc   +1 more source