Results 91 to 100 of about 317,847 (188)

Respiratory enterovirus D68: virology, clinical surveillance, host-pathogen interactions, and therapeutic prospects

Frontiers in Cellular and Infection Microbiology
Enterovirus D68 (EV-D68), a unique enterovirus resembling human rhinoviruses, was long considered to cause only sporadic outbreaks of mild, self-limiting respiratory infections mainly in children.
Yanshan Gui, Bing Han, Jialong Wei, Danlei Sun, Laixian Zhou, Shuchen Yuan, Wenzhan Xie, Hui Feng   +7 more
doaj   +1 more source

Rezafungin Utilisation in Real Life—FungiScope Results From Europe and the United States

Mycoses, Volume 68, Issue 9, September 2025.
ABSTRACT Background Rezafungin, a novel echinocandin with once‐weekly intravenous dosing, offers potential advantages for outpatient parenteral antifungal therapy (OPAT) in invasive candidiasis (IC). While clinical trial data support its efficacy and safety, real‐world experience remains limited.
Ilana Reinhold, Giovanni Mori, Massimiliano Lanzafame, Alessandro Limongelli, Antonio Vena, Julia Götz, Stilla Bauernfeind, Frank Hanses, Lukas Tometten, Michael Mayer, Ansgar Rieke, Ana Soriano‐Martin, Maricela Valerio, Jose A. Vazquez, Patrick Yue, Laman Rahimli, Nijat Azimli, Ertan Sal, Jon Salmanton‐García, Natalia Vasenda, Rosanne Sprute, Jannik Stemler, Sebastian Wingen‐Heimann, Oliver A. Cornely, Danila Seidel   +24 more
wiley   +1 more source

The Mathematics of Serocatalytic Models With Applications to Public Health Data

Statistics in Medicine, Volume 44, Issue 15-17, July 2025.
ABSTRACT Serocatalytic models are powerful tools which can be used to infer historical infection patterns from age‐structured serological surveys. These surveys are especially useful when disease surveillance is limited and have an important role to play in providing a ground truth gauge of infection burden.
Everlyn Kamau, Junjie Chen, Sumali Bajaj, Nicolás Torres, Richard Creswell, Jaime A. Pavlich‐Mariscal, Christl Donnelly, Zulma Cucunubá, Ben Lambert   +8 more
wiley   +1 more source

Pterostilbene Exhibits Broad‐Spectrum Antiviral Activity by Targeting the Enterovirus Capsid, Inactivating Viral Particles, Blocking Viral Binding, and Protecting Mice From Lethal EV‐A71 Challenge

Phytotherapy Research, Volume 39, Issue 6, Page 2672-2688, June 2025.
Pterostilbene (Pte) binds to the VP1 hydrophobic pocket of enteroviruses, stabilizing the viral capsid and preventing uncoating and RNA release. In vitro, Pte inactivates virions and impairs viral attachment, entry, and replication. In vivo, oral administration of Pte in hSCARB2‐transgenic mice reduces clinical symptoms and improves survival ...
Kuan‐Ting Chuang, Siao‐Cian Pan, Bor‐Luen Chiang, Shih‐Hsun Chen, Min‐Hsiung Pan, Yu‐Li Chen, Cheng‐Sheng Lin, Chun‐Kai Pan, Jing‐Yi Lin, Yu‐Li Lin   +9 more
wiley   +1 more source

Synthesis and Evaluation of EV-D68 3C Protease Inhibitors

Enterovirus-D68 (EV-D68) causes acute respiratory infections in children that can lead to acute flaccid myelitis, representing a significant global public health concern.
Murphy, Julia
core   +2 more sources

Clinical Outcomes of Children with EV-D68 or RV/EV infections during the 2014 Outbreak.

, 2016
Clinical Outcomes of Children with EV-D68 or RV/EV infections during the 2014 Outbreak.
Amy Leber (3359129), Douglas Salamon (3359132), Huanyu Wang (332909), Asuncion Mejias (173484), Katherine Moyer (3359135)   +4 more
core   +1 more source

Enterovirus D68 Subgenotype B3 Circulation in Children with Acute Respiratory Illness in the State of Alagoas, Brazil

Viruses
Enterovirus D68 (EV-D68) is a leading cause of acute respiratory disease outbreaks, especially among children. EV-D68 infections can rapidly progress to severe clinical complications and potentially fatal outcomes.
Alex Ranieri Jerônimo Lima, Hazerral de Oliveira Santos, James Siqueira Pereira, Anderson Brandão Leite, Jean Phellipe Marques do Nascimento, Juliana Vanessa Cavalcante Souza, Marlon Breno Zampieri Lima, Mykaella Andrade de Araújo, Marta Giovanetti, Esper Georges Kallas, Sandra Coccuzzo Sampaio, Maria Carolina Elias, Svetoslav Nanev Slavov   +12 more
doaj   +1 more source

Differentiating EV-D68 from HRV by RVP signal of 50nA.

, 2015
Differentiating EV-D68 from HRV by RVP signal of 50nA.
Sophie Arbefeville (708895), Marie E. Steiner (708896), Mark R. Schleiss (463563), Ryan S. Hanson (708897), Patricia Ferrieri (708899), Shane C. McAllister (708894), Catherine Pollock (708898)   +6 more
core   +1 more source

European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014 [PDF]

, 2015
Background: In August and September 2014, unexpected clusters of enterovirus-D68 (EV-D68) infections associated with severe respiratory disease emerged from North-America.
Lina, Bruno, Vuorinen, Tytti, ESCV-ECDC EV-D68 Study Grp, Van Leer-Buter, Coretta, Niesters, Hubert G. M., Jääskeläinen, Anne, Josset, Laurence, Lappalainen, Maija, Schuffenecker, Isabelle, Poelman, Randy, Smura, Teemu   +10 more
core   +1 more source

Mitophagosomes induced during EV-D68 infection promote viral nonlytic release

Abstract Enterovirus-D68 (EV-D68) is a plus-strand RNA virus that primarily causes infant respiratory infections. In rare pediatric cases, infection with EV-D68 has been associated with acute flaccid myelitis, a polio-like paralytic disease. We have previously demonstrated that EV-D68 induces nonselective autophagy for its benefit. Here,
Alagie Jassey, Bimal Paudel, Michael A. Wagner, Noah Pollack, I-Ting Cheng, Raquel Godoy-Ruiz, David J. Weber, William T. Jackson   +7 more
openaire   +2 more sources