Results 61 to 70 of about 317,847 (188)

Enterovirus D68 vRNA induces type III IFN production via MDA5

Virus Research
Enterovirus D68 (EV-D68) primarily spreads through the respiratory tract and causes respiratory symptoms in children and acute flaccid myelitis (AFM). Type III interferons (IFNs) play a critical role in inhibiting viral growth in respiratory epithelial ...
Chi-Chong Chio, Hio-Wai Chan, Shih-Hsiang Chen, Hsing-I Huang   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, Volume 600, Issue 17, Page 2526-2546, September 2026.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

EV-D68 infects anterior horn motor neurons and results in motor neuron death.

, 2017
(A) A cervical spinal cord section at 100X original magnification from a mouse injected intracerebrally with EV-D68 MO/14-18947 that developed right forelimb paralysis on day 4 post-injection.
Penny Clarke (3775216), Kenneth L. Tyler (3775222), Shigeo Yagi (214133), J. Smith Leser (3775213), Alison M. Hixon (3775219), Charles Y. Chiu (123228), Guixia Yu (123189)   +6 more
core   +1 more source

EV-D68 and EV-D94 tropism and IFN-λ induction in 3 different respiratory tissue culture models.

, 2022
The models are derived from human upper (EpiAirway) (A) and lower (SmallAir) (B) respiratory tract and from primary alveolar epithelial cells co-cultured with pulmonary endothelial cells, fibroblasts and THP-1 macrophages (EpiAlveolar) (C).
Julien Prados (743297), Song Huang (46474), Isabelle Piuz (25026), Han Kang Tee (3115308), Samuel Constant (2455153), Ines Cordeiro Filipe (5849144), Caroline Tapparel (74799)   +6 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016 [PDF]

Eurosurveillance, 2016
We report 59 cases of severe paediatric conditions linked with enterovirus (EV)-A71 and EV-D68 in France between May and October 2016. Fifty-two children had severe neurological symptoms. EV sequence-based typing for 42 cases revealed EV-A71 in 21 (18 subgenotype C1, detected for the first time in France) and EV-D68 in eight.
Antona, Denise, Kossorotoff, Manoëlle, Schuffenecker, Isabelle, Mirand, Audrey, Leruez-Ville, Marianne, Bassi, Clément, Aubart, Mélodie, Moulin, Florence, Lévy-Bruhl, Daniel, Henquell, Cécile, Lina, Bruno, Desguerre, Isabelle   +11 more
openaire   +3 more sources

Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review

Viruses, 2019
In 2014, the United States (US) experienced an unprecedented epidemic of enterovirus D68 (EV-D68)-induced respiratory disease that was temporally associated with the emergence of acute flaccid myelitis (AFM), a paralytic disease occurring predominantly ...
Alison M. Hixon, Joshua Frost, Michael J. Rudy, Kevin Messacar, Penny Clarke, Kenneth L. Tyler   +5 more
doaj   +1 more source

Molecular Types of Rhinovirus Among Cases of Acute Respiratory Infections in a University Hospital

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Rhinovirus (RV) is classified in the Picornaviridae family in the Enterovirus genus and consists of three species, RV‐A, RV‐B, and RV‐C, and there are over 170 RV subtypes. This study aimed to make molecular typing of RVs detected in nasopharyngeal swab samples sent to Bursa Uludag University Hospital PCR laboratory and to determine the ...
Beyza Tuner, Harun Agca
wiley   +1 more source

Contemporary enterovirus-D68 isolates infect human spinal cord organoids

mBio, 2023
Enterovirus D68 (EV-D68) is a nonpolio enterovirus associated with severe respiratory illness and acute flaccid myelitis (AFM), a polio-like illness causing paralysis in children.
Gabrielle Aguglia, Carolyn B. Coyne, Terence S. Dermody, John V. Williams, Megan Culler Freeman   +4 more
doaj   +1 more source

Lung Microbiome Diversity, Infection Dynamics, and Microbe‐Mediated Cross‐Protection

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The protective role of the lung microbiome in maintaining respiratory health by promoting immune homeostasis, pathogen exclusion, and barrier integrity. Diverse microbial communities regulate immune maturation, enhance epithelial defenses, and contribute to antiviral responses, collectively preventing pathogen colonization and sustaining a balanced ...
Sana Arooj, Akmal Zubair, Syeda Zaira Batool, Granaz Niaz, Muhammad Ali, Yasir Waheed, Eman Ramadan Elsharkawy, Naila Afghan   +7 more
wiley   +1 more source