Results 61 to 70 of about 248,805 (183)
Advanced Science, EarlyView.By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang +13 more
wiley +1 more source
EV-D68 causes paralysis after intranasal and intramuscular infection.
, 2017 (A) An image of a day 3 post-infection mouse with new onset left hindlimb paralysis following intramuscular injection of EV-D68 strain MO/14-18947. (B) Lumbar spinal cord sections (100X original magnification) from an intramuscular-injected mouse at day ...
Penny Clarke (3775216) +6 more
core +1 more source
Enterovirus D68 vRNA induces type III IFN production via MDA5
Virus ResearchEnterovirus D68 (EV-D68) primarily spreads through the respiratory tract and causes respiratory symptoms in children and acute flaccid myelitis (AFM). Type III interferons (IFNs) play a critical role in inhibiting viral growth in respiratory epithelial ...
Chi-Chong Chio +3 more
doaj +1 more source
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
, 2023 (A) Viral load of EV-D68 detected by qPCR in the supernatant in the presence and absence of itraconazole (ITZ). Points represent mean values. Error bars represent the SD.
Salvatore Simmini (9729704) +12 more
core +1 more source
Cell Reports, 2018 Summary: Enterovirus D68 (EV-D68) is a medically important respiratory plus-strand RNA virus of children that has been linked to acute flaccid myelitis. We have determined that EV-D68 induces autophagic signaling and membrane formation.
Abigail K. Corona +3 more
doaj +1 more source
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT Severe rhinovirus (RV)/enterovirus (EV) respiratory infections in pediatric patients increased in the US during 2022–2023. This study aimed to characterize RV/EV genetic diversity among hospitalized children in Wisconsin and describe demographic and clinical factors of patients by RV/EV type.
Hannah L. Litwak +13 more
wiley +1 more source
EV-D68 infects anterior horn motor neurons and results in motor neuron death.
, 2017 (A) A cervical spinal cord section at 100X original magnification from a mouse injected intracerebrally with EV-D68 MO/14-18947 that developed right forelimb paralysis on day 4 post-injection.
Penny Clarke (3775216) +6 more
core +1 more source
The EV-D68 neutralizing antibody test v1
, 2019 This protocol describes the process forthe neutralizing antibody test of EV-D68.
Jian-Te Lee +6 more
openaire +1 more source
Severe paediatric conditions linked with EV-A71 and EV-D68, France, May to October 2016 [PDF]
Eurosurveillance, 2016 We report 59 cases of severe paediatric conditions linked with enterovirus (EV)-A71 and EV-D68 in France between May and October 2016. Fifty-two children had severe neurological symptoms. EV sequence-based typing for 42 cases revealed EV-A71 in 21 (18 subgenotype C1, detected for the first time in France) and EV-D68 in eight.
Antona, Denise +11 more
openaire +3 more sources