Results 71 to 80 of about 294,887 (257)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Pedestrian, Crowd, and Evacuation Dynamics

, 2013
This contribution describes efforts to model the behavior of individual pedestrians and their interactions in crowds, which generate certain kinds of self-organized patterns of motion. Moreover, this article focusses on the dynamics of crowds in panic or
A Borgers, A Johansson, A Johansson, A Mintz, A Seyfried, BD Hankin, BD Jacobs, C Burstedde, CW Reynolds, D Elliott, D Garbrecht, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, D Helbing, E Quarantelli, F Radjai, G LeBon, G Peng, GG Løvås, GH Ristow, GK Still, H Klüpfel, H-H Stølum, HH Kelley, HW Hamacher, I Rodríguez-Iturbe, J Kerridge, J Klockgether, J Pauls, J Surowiecki, J Tubbs, JJ Fruin, JL Bryan, JP Keating, K Ando, K Lewin, KR Sreenivasan, LF Henderson, LP Kadanoff, M Ebihara, M Fukui, M Isobe, M Muramatsu, ME Cates, N Ashford, N Ketchell, NE Miller, NE Miller, NJ Smelser, NR Johnson, NS Glance, P Bak, PA Johnson, PA Thompson, PG Gipps, R Axelrod, R Axelrod, R Brown, RH Turner, RL Hughes, S Ghashghaie, S Hoogendoorn, S Okazaki, SJ Older, SJ Yuhaski Jr, SP Hoogendoorn, T Baeck, T Kretz, T Schelling, Transportation Research Board, VJ Blue, VM Predtechenskii, WH Whyte   +87 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Creation of a New Industrial Area in the Ulyanovsk District of the Middle Volga Region during the Great Patriotic War in 1941-1943

RUDN Journal of Russian History, 2020
The presented article shows huge, multifaceted work, which in one of the most important economic districts of the country was carried out by local authorities, directors of large industrial enterprises, public organizations on restructuring into military
Evgeniy A. Khapaev
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Estimation of the Logit model for the online contraflow problem

Transport, 2010
Contraflow or lane reversal is an efficient way for increasing the outbound capacity of a network by reversing the direction of in-bound roads during evacuations.
H. Nassiri, A. Edrissi, H. Alibabai
doaj   +3 more sources

Ship design with the human factor: evacuation and normal operations modelling in the ship design process [PDF]

, 2012
This thesis addresses the modelling of human factors and how they can impact ship design. Two different but related applications areas are considered; passenger ship evacuation analysis and naval vessel normal operations and evacuation analysis.
Deere, Steven John
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Evacuation of the German Population from Transnistria in March–July 1944

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2020
Introduction. During autumn 1943 – spring 1944 the systematic phased evacuation of the German population was carried out from the occupied Soviet regions.
Vladimir L. Martynenko
doaj   +1 more source

Development Of Planning Support System For Urban Rehabilitation And Reconstruction In Case Sidoarjo Mud Flow Post Disaster [PDF]

, 2011
Sidoarjo mud disaster impact that has lasted more than 3 years are very influential on other aspects of life in Porong and surrounding areas. The need for information systems that can inform the public about the catastrophic conditions is absolutely ...
Arna, Fariza, M. Syamsul, Hudha, Muhamad, Bayu AS, Rosita, Vebriesti Ratri, Wahjoe, Tjatur Sesulihatien   +4 more
core