Results 91 to 100 of about 1,765 (298)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

open access: yesFEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Locating and Capturing an Evader in a Polygonal Environment [PDF]

open access: yes, 2003
This paper contains two main results: First, we revisit the well-known visibility based pursuit-evasion problem and show that, in contrast to deterministic strategies, a single pursuer can locate an unpredictable evader in any simplyconnected polygonal ...
Sampath Kannan   +5 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

open access: yesFEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Research on Pursuit-evasion Games with Multiple Heterogeneous Pursuers and A High Speed Evader

open access: yes, 2015
We deal with Pursuit-evasion games with a high speed evader which has superiority in velocity over a group of heterogeneous pursuers in this paper. Heterogeneity in the group of pursuers is expressed as heterogeneity in the individual maximum speeds.
Liu JT(刘景泰)   +2 more
core  

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

open access: yesFEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto   +14 more
wiley   +1 more source

Topology-Safe Air-to-Air Interception via “Go”-Inspired Metrics and Multi-Agent Reinforcement Learning

open access: yesAerospace
Airspace defense against agile UAVs requires multiple defenders to cooperatively encircle evasive intruders, but existing formation controllers cannot certify when an intruder is truly trapped.
Kai Ye   +6 more
doaj   +1 more source

Optimizing evasive strategies for an evader with imperfect vision capacity

open access: yes, 2019
The multiagent pursuit-evasion problem has attracted considerable interest during recent years, and a general assumption is that the evader has perfect vision capacity.
Yang, Shaofu   +6 more
core   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

open access: yesFEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller   +3 more
wiley   +1 more source

Simple motion evasion differential game of multiple pursuers and single evader with integral constraints on control function [PDF]

open access: yes, 2013
The term “Differential games” is applied to a group of problems in applied mathematics that share certain characteristics related to the modelling of conflict.
Salleh, Yusra
core   +1 more source

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