Results 71 to 80 of about 1,484 (240)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Interdiction of a Markovian Evader

, 2011
Shortest path network interdiction is a combinatorial optimiza-tion problem on an activity network arising in a number of im-portant security-related applications.
Aric A. Hagberg, David Izraelevitz, Alexander Gutfraind, Feng Pan, Er Gutfraind, Aric Hagberg   +5 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Solution of a Linear Pursuit-Evasion Differential Game with Closed and Convex Terminal Set

Journal of Mathematical and Fundamental Sciences, 2013
A linear two-person zero-sum pursuit-evasion differential game is considered. Control functions of players are subject to integral constraints. Terminal set is a closed convex subset of  The Pursuer tries to bring the state of the system to the terminal ...
Gafurjan I. Ibragimov, Marzieh Khakestari, Atamurat Sh. Kuchkarov   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Interactive Multiple-Model Learning Filter for Spacecraft Pursuit–Evasion Game Strategy Switch Based on Long Short-Term Memory Network

Aerospace
Aiming to address the problem of pursuit and interception for spacecraft using multiple evasion strategies, a pursuit strategy involving the use of an interactive multiple-model filter (IMM) in a pursuit–evasion game is considered, where the Evader ...
Chuangge Wang, Danhe Chen, Wenhe Liao
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

An Overview of Recent Advances in Pursuit–Evasion Games with Unmanned Surface Vehicles

Journal of Marine Science and Engineering
With the rapid development of perception, decision-making, and control technologies, pursuit–evasion (PE) games with unmanned surface vehicles (USVs) have become an interesting research topic in military implementations and civilian areas. In this paper,
Xingru Qu, Linghui Zeng, Shihang Qu, Feifei Long, Rubo Zhang   +4 more
doaj   +1 more source

A Multiplayer Pursuit Differential Game on a Closed Convex Set with Integral Constraints

Abstract and Applied Analysis, 2012
We study a simple motion pursuit differential game of many pursuers and many evaders on a nonempty convex subset of . In process of the game, all players must not leave the given set.
Gafurjan Ibragimov, Nu'man Satimov
doaj   +1 more source