Results 71 to 80 of about 1,765 (298)

On a linear differential game of optimal approach of many pursuers with one evader [PDF]

, 2013
We consider a differential game of approach of many pursuers and one evader. The motions of all players are described by linear systems of the same type. Control functions of players are subject to integral constraints. The duration of the game is fixed.
Ibragimov, Gafurjan, Khakestari, Marzieh, Kuchkarov, Atamurat Shamuratovich   +2 more
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

SOLUTION OF SIMPLE PURSUIT-EVASION PROBLEM WHEN EVADER MOVES ON A GIVEN CURVE

, 2010
We investigate a simple motion pursuit-evasion differential game of one Pursuer and one Evader. Maximal speeds of the players are equal. The Evader moves along a given curve without self-intersection.
ATAMURAT SH. KUCHKAROV
core   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Interactive Multiple-Model Learning Filter for Spacecraft Pursuit–Evasion Game Strategy Switch Based on Long Short-Term Memory Network

Aerospace
Aiming to address the problem of pursuit and interception for spacecraft using multiple evasion strategies, a pursuit strategy involving the use of an interactive multiple-model filter (IMM) in a pursuit–evasion game is considered, where the Evader ...
Chuangge Wang, Danhe Chen, Wenhe Liao
doaj   +1 more source

A Multiplayer Pursuit Differential Game on a Closed Convex Set with Integral Constraints

Abstract and Applied Analysis, 2012
We study a simple motion pursuit differential game of many pursuers and many evaders on a nonempty convex subset of . In process of the game, all players must not leave the given set.
Gafurjan Ibragimov, Nu'man Satimov
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

An Overview of Recent Advances in Pursuit–Evasion Games with Unmanned Surface Vehicles

Journal of Marine Science and Engineering
With the rapid development of perception, decision-making, and control technologies, pursuit–evasion (PE) games with unmanned surface vehicles (USVs) have become an interesting research topic in military implementations and civilian areas. In this paper,
Xingru Qu, Linghui Zeng, Shihang Qu, Feifei Long, Rubo Zhang   +4 more
doaj   +1 more source

Solution of a Linear Pursuit-Evasion Differential Game with Closed and Convex Terminal Set

Journal of Mathematical and Fundamental Sciences, 2013
A linear two-person zero-sum pursuit-evasion differential game is considered. Control functions of players are subject to integral constraints. Terminal set is a closed convex subset of  The Pursuer tries to bring the state of the system to the terminal ...
Gafurjan I. Ibragimov, Marzieh Khakestari, Atamurat Sh. Kuchkarov   +2 more
doaj   +1 more source