Results 61 to 70 of about 1,765 (298)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

On Linear Pursuit-Evasion Game Problems with GGr-Constraints on Controls of Players

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
This article investigates a differential game of pursuit-evasion for linear motion dynamics of two players, a pursuer and an evader. The pursuer’s control is subject to a geometric constraint (its Euclidean norm does not exceed a given constant α), while
Juraev, B.I.
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Detectability and annoyance of warning sounds for electric vehicles

, 2013
International audienceElectric or hybrid vehicles are very quiet at low speeds, which represents a very good opportunity to reduce traffic noise annoyance in cities. On the other hand, this may be very hazardous for vulnerable pedestrians (e.g.
Schlittenlacher, Joseph, Parizet, Etienne, Speed-Andrews, Paul, Cockram, James, Hatton, Gemma, Robart, Ryan, Ellermeier, Wolfgang, Chamard, Jean-Christophe, Pondrom, Perceval, Janssens, Karl, Biancardi, Fabio   +10 more
core   +4 more sources

QUANTITATIVE ANALYSIS OF THE PROBLEM OF LION AND MAN IN THE PRESENCE OF A CIRCULAR OBSTACLE

Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2020
In this work, we consider the problem of Lion and Man in the sense of l-capture, i.e. hit some neighborhood in the presence of a circular obstacle. A structure is proposed for constructing piecewise-constant pursuit controls that ensure the completion ...
М.Ш. Маматов, А.О. Зуннунов, Е.Е. Есонов   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Evader Surveillance Under Incomplete Information [PDF]

, 2009
— This paper is concerned with determining whether a mobile robot, called the pursuer , is up to maintain- ing visibility of an antagonist agent, called the evader . This problem, a variant of pursuit-evasion , has been largely studied,
RAFAEL ERIC MURRIETA CID
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Evading Evasion

Sciential - McMaster Undergraduate Science Journal, 2018
The CRISPR-Cas9 system has paved the way for realizing gene-editing, but its main weakness lies in its potential for off-target effects. Studies into phages reveal that they express “anti-CRISPR” proteins which if harnessed, could provide us with the solution to this lack of control.
openaire   +2 more sources