Results 61 to 70 of about 1,484 (240)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

On Linear Pursuit-Evasion Game Problems with GGr-Constraints on Controls of Players

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
This article investigates a differential game of pursuit-evasion for linear motion dynamics of two players, a pursuer and an evader. The pursuer’s control is subject to a geometric constraint (its Euclidean norm does not exceed a given constant α), while
Juraev, B.I.
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Additional Efficient Warning Sounds for Electric and Hybrid Vehicles

, 2014
International audienceElectric or hybrid vehicles are very silent, which represents a major advantage for the reduction of noise annoyance in urban areas.
Jean-Christophe Chamard, Parizet, Etienne, Guillaume Baudet, Karl Janssens, Quinn, David, David Quinn, Chamard, Jean-Christophe, Ryan Robart, Janssens, Karl, Haider, Manfred, Baudet, Guillaume, Perceval Pondrom, Robart, Ryan, Manfred Haider, Etienne Parizet, Pondrom, Perceval   +15 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Pursuit-evasion games with multi-pursuer vs. one fast evader

, 2010
In a pursuit-evasion (PE) game, each pursuer attempts to minimize the distance between the pursuer (P) and the evader (E) and capture it in the shortest time, whereas the evader tries to maximize the distance to escape from being captured. In this paper,
null Zhihua Qu, Jin, Shiyuan, null Shiyuan Jin, Qu, Zhihua   +3 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

QUANTITATIVE ANALYSIS OF THE PROBLEM OF LION AND MAN IN THE PRESENCE OF A CIRCULAR OBSTACLE

Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2020
In this work, we consider the problem of Lion and Man in the sense of l-capture, i.e. hit some neighborhood in the presence of a circular obstacle. A structure is proposed for constructing piecewise-constant pursuit controls that ensure the completion ...
М.Ш. Маматов, А.О. Зуннунов, Е.Е. Есонов   +2 more
doaj   +1 more source