Results 61 to 70 of about 5,205 (290)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Least-core and Nucleolus of Path Cooperative Games

, 2015
Cooperative games provide an appropriate framework for fair and stable profit distribution in multiagent systems. In this paper, we study the algorithmic issues on path cooperative games that arise from the situations where some commodity flows through a
A Washburn, D Schmeidler, E Kalai, G Chalkiadakis, H Reijnierse, J Potters, Q Fang, T Solymosi, U Faigle, U Faigle, W Kern, X Deng, X Deng, Y Bachrach   +13 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

On Linear Pursuit-Evasion Game Problems with GGr-Constraints on Controls of Players

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
This article investigates a differential game of pursuit-evasion for linear motion dynamics of two players, a pursuer and an evader. The pursuer’s control is subject to a geometric constraint (its Euclidean norm does not exceed a given constant α), while
Juraev, B.I.
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

QUANTITATIVE ANALYSIS OF THE PROBLEM OF LION AND MAN IN THE PRESENCE OF A CIRCULAR OBSTACLE

Міжнародний науково-технічний журнал "Проблеми керування та інформатики", 2020
In this work, we consider the problem of Lion and Man in the sense of l-capture, i.e. hit some neighborhood in the presence of a circular obstacle. A structure is proposed for constructing piecewise-constant pursuit controls that ensure the completion ...
М.Ш. Маматов, А.О. Зуннунов, Е.Е. Есонов   +2 more
doaj   +1 more source

The 2-evader problem

Information Processing Letters, 1996
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Koutsoupias, E, Papadimitriou, C
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evading the Goldstone theorem [PDF]

Annalen der Physik, 2014
Peter W. Higgs describes in detail his interest from 1960 in the work of Nambu and Goldstone and the background events leading to the papers of 1964 that showed how one can evade the Goldstone theorem using a gauge theory. He also discusses how these ideas have been developed by others to culminate in the electroweak theory of the Standard Model.
openaire   +1 more source