Results 41 to 50 of about 1,484 (240)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

A Sequential Game Framework for Target Tracking

IEEE Access
This paper investigates the application of game-theoretic principles combined with advanced Kalman filtering techniques to enhance maritime target tracking systems.
Daniel Leal, Ngoc Hung Nguyen, Alex Skvortsov, Sanjeev Arulampalam, Mahendra Piraveenan   +4 more
doaj   +1 more source

An Approach for Solving Discrete Game Problems with Total Constraints on Controls

Abstract and Applied Analysis, 2014
We consider a linear pursuit game of one pursuer and one evader whose motions are described by different-type linear discrete systems. Controls of the players satisfy total constraints.
Asqar Raxmonov, Gafurjan I. Ibragimov
doaj   +1 more source

PURSUIT-EVASION DIFFERENTIAL GAMES WITH THE GRÖNWALL TYPE CONSTRAINTS ON CONTROLS

Ural Mathematical Journal, 2020
A simple pursuit-evasion differential game of one pursuer and one evader is studied. The players' controls are subject to differential constraints in the form of the integral Grönwall inequality.
Bahrom T. Samatov, Gafurjan Ibragimov, Iroda V. Khodjibayeva   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Adaptive Control of Run‐and‐Tumble Escape in Pursuit‐Evasion Dynamics of Intelligent Active Particles

Advanced Intelligent Systems
The pursuit‐evasion game is studied for two adversarial active agents, modeled as a deterministic self‐steering pursuer and a stochastic, cognitive evader. The pursuer chases the evader by reorienting its propulsion direction with limited maneuverability,
Segun Goh, Dennis Haustein, Gerhard Gompper   +2 more
doaj   +1 more source

Pursuit-evasion game of many players with coordinate-wise integral constraints on a convex set in the plane

Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2017
We study a differential game of many pursuers and one evader in the plane. It is assumed that the pursuers and evader move is allowed within a non empty closed convex set in the plane.
Massimiliano Ferrara, Gafurjan I. Ibragimov, Mehdi Salimi   +2 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

WARNING SOUNDS FOR ELECTRIC VEHICLES

, 2014
International audienceElectric vehicles (or hybrid ones) are very silent at low speeds (below 30 km/h) and can be dangerous for pedestrian, especially vulnerable ones as visually impaired people.
Parizet, Etienne, Robart, Ryan, Quinn, David, Ellermeier, Wolfgang, Chamard, Jean-Christophe, Janssens, Karl, Haider, Manfred, Biancardi, Fabio   +7 more
core   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source