Results 41 to 50 of about 305,125 (284)

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Science, 2020
A viral block on host protein synthesis As the coronavirus disease 2019 (COVID-19) pandemic continues to cause devastation, scientists race to increase their understanding of the disease-causing severe acute respiratory syndrome coronavirus 2.
M. Thoms, R. Buschauer, M. Ameismeier, L. Koepke, T. Denk, M. Hirschenberger, H. Kratzat, Manuel Hayn, T. Mackens-Kiani, Jingdong Cheng, J. H. Straub, C. Stürzel, T. Fröhlich, O. Berninghausen, T. Becker, F. Kirchhoff, Konstantin M. J. Sparrer, R. Beckmann   +17 more
semanticscholar   +1 more source

EL PROYECTO BEPS DE LA OCDE/G20: RESULTADOS DE 2014 [PDF]

Crónica Tributaria, 2015
La extremadamente agresiva planificación fiscal llevada a cabo por determinadas multinacionales a nivel internacional ha obligado a los países a buscar soluciones coordinadas para hacer frente a este problema común.
Mar Barreno, Jorge Ferreras, Jaime Mas, Antoinette Musilek, Alfredo Ranz   +4 more
doaj  

Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455–456 synergistically enhances antibody evasion and ACE2 binding

bioRxiv, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB lineages have achieved dominance worldwide and keep on evolving. Convergent evolution of XBB lineages on the receptor-binding domain (RBD) L455F and F456L is observed, resulting in variants
F. Jian, Sijie Yang, Yuanling Yu, Weiliang Song, A. Yisimayi, Xiaosu Chen, Yanli Xu, Peng Wang, Lingling Yu, Jing Wang, Lu Liu, Xiaowei Niu, Jing Wang, T. Xiao, R. An, Yao Wang, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Yunlong Cao   +21 more
semanticscholar   +1 more source

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

Nature Communications
The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral sublineages. Here, we isolate and characterize XBB.1, XBB.1.5, XBB.1.9.1, XBB.1.16.1, EG.5.1.1, EG.5.1.3, XBF, BA.2.86.1 and JN.1 variants, representing >80% of ...
Delphine Planas, I. Staropoli, Vincent Michel, F. Lemoine, F. Donati, M. Prot, F. Porrot, F. Guivel-Benhassine, Banujaa Jeyarajah, Angela Brisebarre, Océane Dehan, Léa Avon, William Bolland, Mathieu Hubert, Julian Buchrieser, Thibault Vanhoucke, Pierre Rosenbaum, D. Veyer, H. Péré, Bruno Lina, S. Trouillet-Assant, L. Hocqueloux, T. Prazuck, E. Simon-Lorière, Olivier Schwartz   +24 more
semanticscholar   +1 more source

Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation

Nature Communications, 2023
The recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response.
Wanzun Lin, Li Chen, Haojiong Zhang, Xianxin Qiu, Qingting Huang, Fangzhu Wan, Z. Le, Shikai Geng, Anlan Zhang, S. Qiu, Long Chen, L. Kong, Jiade J. Lu   +12 more
semanticscholar   +1 more source

The role of tumor-associated macrophages in tumor immune evasion

Journal of Cancer Research and Clinical Oncology
Tumor growth is closely linked to the activities of various cells in the tumor microenvironment (TME), particularly immune cells. During tumor progression, circulating monocytes and macrophages are recruited, altering the TME and accelerating growth ...
Ruizhe Huang, Ting Kang, Siyu Chen
semanticscholar   +1 more source

Evolution of enhanced innate immune evasion by SARS-CoV-2

Nature, 2021
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission1,2. Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of ...
Lucy G. Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, L. Zuliani-Alvarez, Benjamin J. Polacco, A. Pelin, J. Batra, M. Whelan, M. Hosmillo, A. Fossati, Roberta Ragazzini, Irwin Jungreis, Manisha Ummadi, Ajda Rojc, Jane Turner, Marie L. Bischof, K. Obernier, Hannes Braberg, Margaret Soucheray, Alicia L. Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, J. Hiatt, R. Rosales, B. McGovern, A. Jahun, Jacqueline M. Fabius, K. White, I. Goodfellow, Yasuyuki Takeuchi, P. Bonfanti, K. Shokat, N. Jura, K. Verba, M. Noursadeghi, P. Beltrão, Manolis Kellis, D. Swaney, A. García-Sastre, C. Jolly, G. Towers, N. Krogan   +42 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

La conducta humana del contribuyente en el cumplimiento de sus obligaciones fiscales

Revista Visión Contable
La evasión de impuestos representa uno de los mayores retos a los que ha tenido que enfrentarse los gobiernos a nivel global, ya que es una problemática que no solo se vive en los países en vía de desarrollo sino también en los países desarrollados. Por
Ana Cristina Melguizo Betancur
doaj   +1 more source

El malestar del ser: Levinas, el hitlerismo y la evasión como revuelta

Mutatis Mutandis: Revista Internacional de Filosofía, 2019
El artículo se propone leer los ensayos de Levinas: Algunas reflexiones sobre la filosofía del hitlerismo y De la evasión como dos capítulos de un mismo discurso en el cual el autor muestra cual pueden ser los peligros y los riesgos de un pensamiento ...
Matilde Orlando
doaj   +1 more source