Results 191 to 200 of about 49,849 (236)

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

Advanced Science, EarlyView.
We fabricated a thermoelectric nanomedicine to disrupt the ATP energy supply for the copper transporter ATP7B, thereby enhancing cuproptosis and achieving synergistic immunotherapy for anti‐tumor purposes. The fabricated TBCT NFs can efficiently disrupt the electron transport chain function via superoxide‐induced NADH oxidation, leading to ATP ...
Haoyang Du, Chao Xu, Hao Wang, Bo Peng, Peng Liu, Wei Gao, Tao Ye, Xinyuan Yu, Ying Shi, Jiaxin Liu, Tiancong Zhao, Bin Sun, Piaoping Yang, Manjie Zhang   +13 more
wiley   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

An Evasive Maneuvering Algorithm for UAVs in Sense-and-Avoid Situations

, 2009
openaire   +2 more sources

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Planar Evasive Aircrafts Maneuvers Using Reinforcement Learning

Advances in Intelligent Systems and Computing, 2013
In this paper, the reinforcement learning technique is proposed to implement evasive strategies for aircrafts during engagement. A simplified point-mass model is used to describe the aircraft and the missile equations of motion. The missile follows the pure proportional navigation guidance (PPNG) law to attack the aircraft.
Hyochoong Bang
exaly   +2 more sources

Aircraft Evasive Maneuver Trajectory Optimization Based on QPSO

International Congress on Ultra Modern Telecommunications and Control Systems, 2010
This paper introduces a parameterization method for obtaining closed-loop suboptimal solutions to the aircraft evasive maneuver problem, which is transformed into a nonlinear programming problem using Quantum-behaved Particle Swarm Optimization (QPSO) algorithm based on rolling optimization concept.
Dong Xin-Min, Qin-Ying Lin, Xiao-Ping Wang   +2 more
exaly   +2 more sources

Safe Navigation and Evasive Maneuvers Based on Probabilistic Multi-Controller Architecture

IEEE Transactions on Intelligent Transportation Systems, 2022
Automated Driving System (ADS) requires a high fidelity decision-making strategy to palliate to uncertain environment and changing dynamics of other road users. Considering the uniqueness of each traffic situation, the task of modeling every use-case is nearly impossible.
Lounis Adouane, Dimia Iberraken
exaly   +3 more sources

Processing optimized for symmetry in the problem of evasive maneuvers

Computational and Applied Mathematics, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jesus, Antonio Delson C. de, Sousa, Rafael Ribeiro de   +1 more
openaire   +3 more sources