Results 111 to 120 of about 6,906,802 (378)

Does therapeutic massage support mental well-being? [PDF]

open access: yes, 2012
Massage was once a traditional medical practice of many ancient cultures. Today, the practice of modern therapeutic massage is embedded within the field of complementary or alternative medicine (CAM).
Cavaye, Joyce
core   +1 more source

Awareness, attitudes and knowledge about evidence based medicine among doctors in Gaza:A cross sectional survey [PDF]

open access: yes, 2017
Evidence-based medicine (EBM) has emerged as a strategy to integrate research evidence within clinical decision-making. We have explored awareness, knowledge and attitudes about EBM among doctors in the Gaza Strip. In 2014, we conducted a cross-sectional
Albarqouni, Loai, Elessi, Khamis
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Reconstructing data : evidence-Based Medicine and Evidence-Based Public Health in context [PDF]

open access: yes, 2006
The emergence of Evidence-Based Medicine (EBM) as the gold-standard practice in biomedicine and public health practices represents a significant epistemological turn in modern medicine.
Davidovitch, Nadav
core   +6 more sources

Using PICO to Align Medical Evidence with MDs Decision Making Models [PDF]

open access: yes, 2013
Modern medicine is characterized by an “explosion” in clinical research information making practical application of Evidence-Based Medicine (EBM), problematic for many clinicians.
Farion, K.   +3 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Natalizumab in patients with multiple sclerosis in Colombia: a case series

open access: yesActa Neurológica Colombiana, 2020
INTRODUCTION: Natalizumab is a humanized monoclonal antibody prescribed in the treatment of multiple sclerosis, the most prevalent chronic and inflammatory disease of the central nervous system (CNS). NEDA (no evidence of disease activity) status is the
Juan Raúl García Bonitto   +4 more
doaj   +1 more source

Curso de aperfeiçoamento em saúde baseada em evidências por teleconferência [PDF]

open access: yes, 2009
Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Division of Emergency Medicine and Evidence-Based MedicineBrazilian Cochrane CenterAssociação Paulista de ...
Atallah, Álvaro Nagib   +1 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

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