Results 121 to 130 of about 6,906,802 (378)

Developments, Evolution, and Implications of National Diagnostic Criteria for COVID-19 in China

open access: yesFrontiers in Medicine, 2020
Recently WHO has characterized COVID-19 as a pandemic. Diagnosing the disease accurately and decreasing misdiagnoses and missed diagnoses is very important for management.
Lin-Lu Ma   +6 more
doaj   +1 more source

Bad news: analysis of the quality of information on influenza prevention returned by Google in English and Italian [PDF]

open access: yes, 2015
Information available to the public influences the approach of the population toward vaccination against influenza compared with other preventative approaches.
Allam   +38 more
core   +3 more sources

AI-generated text may have a role in evidence-based medicine

open access: yesNature Medicine, 2023
Yifan Peng   +3 more
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Information-theoretic classification of SNOMED improves the organization of context-sensitive excerpts from Cochrane Reviews [PDF]

open access: yes, 2007
The emphasis on evidence based medicine (EBM) has placed increased focus on finding timely answers to clinical questions in presence of patients. Using a combination of natural language processing for the generation of clinical excerpts and information ...
Carol, Friedman   +6 more
core  

Rationalism and Empiricism in Modern Medicine [PDF]

open access: yes, 2001
The roots of rationalism and empiricism in the Hippocratic tradition are explored. The triumph of the rationalists in the founding of modern medicine is emphasized. The development of clinical epidemiology and the evidence-based medicine over the last 30
Newton, Warren
core   +2 more sources

Six ‘biases’ against patients and carers in evidence-based medicine

open access: yesBMC Medicine, 2015
BackgroundEvidence-based medicine (EBM) is maturing from its early focus on epidemiology to embrace a wider range of disciplines and methodologies. At the heart of EBM is the patient, whose informed choices have long been recognised as paramount. However,
T. Greenhalgh   +4 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

PTEN-opathies: from biological insights to evidence-based precision medicine.

open access: yesJournal of Clinical Investigation, 2019
The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN hamartoma tumor syndrome (PHTS), featuring various benign and malignant tumors, as well ...
L. Yehia, J. Ngeow, C. Eng
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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