Results 81 to 90 of about 6,549,758 (385)

A potassium-chloride co-transporter promotes tumor progression and castration resistance of prostate cancer through m6A reader YTHDC1

Cell Death and Disease, 2023
SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported to promote tumor progression, however, the underlying mechanism remains unclear.
Shuai Yuan, Shao-Hua He, Lu-Yao Li, Shu Xi, Hong Weng, Jin-Hui Zhang, Dan-Qi Wang, Meng-Meng Guo, Haozhe Zhang, Shuang-Ying Wang, Dao-Jing Ming, Meng-Yang Liu, Hailiang Hu, Xian-Tao Zeng   +13 more
doaj   +1 more source

Chinese Herbal Medicine Used With or Without Conventional Western Therapy for COVID-19: An Evidence Review of Clinical Studies

Frontiers in Pharmacology, 2021
Objective: To present the evidence of the therapeutic effects and safety of Chinese herbal medicine (CHM) used with or without conventional western therapy for COVID-19.Methods: Clinical studies on the therapeutic effects and safety of CHM for COVID-19 ...
Shi-Bing Liang, Ying-Ying Zhang, Chen Shen, Chang-Hao Liang, Bao-Yong Lai, Ning Dai, Yu-Qi Li, Zi-Yu Tian, Xiao-Wen Zhang, Yue Jiang, Min Xiong, Ya-Peng Zhang, Ying Zhang, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Jian-Ping Liu   +16 more
doaj   +1 more source

Rationalism, Empiricism, and Evidence-Based Medicine: A Call for a New Galenic Synthesis [PDF]

, 2018
Thirty years after the rise of the evidence-based medicine (EBM) movement, formal training in philosophy remains poorly represented among medical students and their educators.
Webb, William
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Dose–response association between maternal pre-pregnancy bodyweight and gestational diabetes mellitus following ART treatment: a population-based cohort study

Reproductive Biology and Endocrinology, 2022
Background The impact of maternal pre-pregnancy bodyweight on gestational diabetes mellitus (GDM) following assisted reproductive technology (ART) treatment has been insufficiently investigated.
Yiquan Xiong, Jing Wang, Yana Qi, Chunrong Liu, Mingxi Li, Guanhua Yao, Wei Sun, Yongyao Qian, Lishan Ye, Hui Liu, Qiushi Xu, Kang Zou, Jing Tan, Xin Sun   +13 more
doaj   +1 more source

Quality healthcare, evidence-based medicine and translational research [PDF]

, 2011
Advances in medical care ensure that with the passage of time we are increasingly able to effectively tackle diverse medical problems. These advances, however, do come at a cost and the benefits derived need to be assessed on a regular basis.
Vassallo, Josanne
core  

Effect of a brief intervention on evidence-based medicine skills of pediatric residents [PDF]

, 2006
BACKGROUND: While Evidence-Based Medicine (EBM) skills are increasingly being taught in medical schools, teaching quality has been insufficient, so that incoming pediatric residents lack adequate EBM skills required for patient care.
A Coomarasamy, A Schwartz, Andrea Markinson, Barbara Lawrence, CA Smith, DL Sackett, Eugene Dinkevich, Evidence Based Medicine Working Group, Evidence Based Medicine Working Group, G Guyatt, G Norman, J Green, K Edwards, K Ramos, L Fritsche, M Green, R Grad, R Hatala, Sama Ahsan, T Ibbottson   +19 more
core   +3 more sources

How to understand and conduct evidence-based medicine

Korean Journal of Anesthesiology, 2016
Evidence-based medicine (EBM) is the conscientious, explicit, and judicious use of current best evidence in making decisions regarding the care of individual patients.
Hyun Kang
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source