Results 101 to 110 of about 1,854,423 (305)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

The complete mitochondrial genome of Aglais ladakensis (Lepidoptera: Nymphalidae: Nymphalinae)

Mitochondrial DNA. Part B. Resources, 2020
We describe the mitogenome sequence of alpine butterfly Aglais ladakensis (Lepidoptera: Nymphalidae: Nymphalinae) collected from the Qilianshan Mountain, Gansu province, China.
Keke Chen, Chengcai Si, Zhongqi Pan, Jiasheng Hao   +3 more
doaj   +1 more source

Ways to solve of the evolution equation in the homogeneous free molecular condensation under dynamic conditions [PDF]

arXiv, 2006
The ways to construct solution of the evolution equation in the homogeneous free molecular condensation under dynamic conditions are presented in parametric form.
arxiv  

Molecular characterization of the evolution of phagosomes

Molecular Systems Biology, 2010
Amoeba use phagocytosis to internalize bacteria as a source of nutrients, whereas multicellular organisms utilize this process as a defense mechanism to kill microbes and, in vertebrates, initiate a sustained immune response. By using a large‐scale approach to identify and compare the proteome and phosphoproteome of phagosomes isolated from distant ...
Jonathan Boulais, Pierre Thibault, Matthias Trost, Matthias Trost, Michel Desjardins, Thierry Soldati, Christian R. Landry, Stephen W. Michnick, Emmanuel D. Levy, Régis Dieckmann   +9 more
openaire   +7 more sources

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

El origen de la vida y la primera molécula capaz de replicarse a sí misma

Revista de Química, 2014
El origen de la vida en la Tierra es una de las preguntas más difíciles presentadas a la ciencia. En los últimos 60 años, ha habido un progreso considerable en entender cómo moléculas relativamente sencillas, que son relevantes para la vida, pueden ser ...
Roberto Laos, Steven Benner
doaj  

Filament L1482 in the California molecular cloud [PDF]

, 2014
Aims. The process of gravitational fragmentation in the L1482 molecular filament of the California molecular cloud is studied by combining several complementary observations and physical estimates. We investigate the kinematic and dynamical states of this molecular filament and physical properties of several dozens of dense molecular clumps embedded ...
arxiv   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

The distributions of protein coding genes within chromatin domains in relation to human disease

Epigenetics & Chromatin, 2019
Background Our understanding of the nuclear chromatin structure has increased hugely during the last years mainly as a consequence of the advances in chromatin conformation capture methods like Hi-C.
Enrique M. Muro, Jonas Ibn-Salem, Miguel A. Andrade-Navarro   +2 more
doaj   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source