Results 51 to 60 of about 251,771 (264)

PHYLOGENETIC SIGNATURES IN THE JUVENILE SKULLS AND CHEEK TEETH OF PLEISTOCENE PROBOSCIDIPPARION SINENSE, CHINA

Rivista Italiana di Paleontologia e Stratigrafia, 2015
We describe and compare three partial skulls of Chinese juvenile Proboscidipparion sinense from the Nihewanian of China. Study of the facial morphology, especially the nasal aperture, as well as cheek tooth morphology and metric data, including length ...
RAYMOND L. BERNOR, KEIKO MESHIDA, BOYANG SUN   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The complete mitochondrial genome sequence and gene organization of Lepidotrigla Kanagashira (Scorpaeniformes, Triglidae) with phylogenetic consideration

Mitochondrial DNA. Part B. Resources, 2020
The complete mitochondrial genome DNA sequence of Lepidotrigla kanagashira was 16,504 bp in length. It consists of 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes and one control region.
Wei Wang, Ming Zhao, Linzi Zhang, Chunyan Ma, Wei Chen, Zhiqiang Liu, Fengying Zhang, Lingbo Ma   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The complete mitochondrial genome of Gephyrocharax atracaudatus (Characiformes, Characidae) and phylogenetic studies of Characiformes

Mitochondrial DNA. Part B. Resources, 2019
Here, we report the complete mitochondrial genome sequence of Gephyrocharax atracaudatus. The genome is found to be 17,049 bp in length and has a base composition of A (29.95%), G (15.29%), C (26.13%) and T (28.63%).
Youkun Huang, Bingjian Liu, Kehua Zhu, Jianshe Zhang, Fei Jing, Liping Xia, Yifan Liu   +6 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Complete mitochondrial genome analysis of Japanese Spanish mackerel (Scomberomorus niphonius) with phylogenetic consideration

Mitochondrial DNA. Part B. Resources, 2017
The complete mitochondrial DNA (mtDNA) of Japanese Spanish mackerel (Scomberomorus niphonius) was cloned and sequenced. The total length of the mitochondrial genome is 16,646 bp with an accession number KY228987.
Yan Jin, Longling Ouyang, Hongxiang Zheng, Yu Lin, Menghan Zhang, Shengfa Li, Jiahua Cheng   +6 more
doaj   +1 more source

Evolutionary relationships between Archaea and eukaryotes

Nature Ecology & Evolution, 2019
A phylogenomic re-analysis of sequence data strongly supports the emergence of eukaryotes from within the archaeal radiation and underlines the importance of using the most accurate approaches to reconstruct ancient divergences in the tree of life.
Gribaldo, Simonetta, Brochier-Armanet, Celine   +1 more
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source