Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Temporal trends in chemical parameters of upland forest soils in southern Finland
Silva Fennica, 2005 Changes in chemical soil properties during periods of 12 to 28 years were studied in 54 stands in southern Finland. Relative slopes (%/year) were calculated for the changes in soil variables in order to utilise all the sampling occasions (2â6 ...
Tamminen, Pekka, Derome, John
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
IMPROVING THE CHEMICAL PROPERTIES OF ACIDIC SOIL WITH AFFORDABLE LIME APPLICATION FOR INCREASING POTATO GROWTH AND YIELDS IN SEDIE DISTRICT, NORTHWESTERN ETHIOPIA [PDF]
مجلة الأنبار للعلوم الزراعيةSoil acidity remains a critical issue in Ethiopia, particularly in the highland regions, where over 43% of arable lands has low pH levels. Enhancing the chemical properties of the soil and subsequent potato growth and yield through affordable lime ...
S. A. Yenesew
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Quantification of aluminium in soil of the Solimões formation, Acre State, Brazil. [PDF]
, 2019 The variety of soils in the State of Acre is wide and their chemical profiles are still not fully understood. The nature of the material of origin of these soils is indicated by the high aluminium (Al) content, commonly associated with high calcium (Ca ...
ANJOS, L. H. C. dos +6 more
core
Evaluation of streamwater composition changes in the Vosges Mountains (NE France): 1955–2005 [PDF]
, 2009 n 1995, in the southwestern Vosges Mountains (NE France), 158 of 395 streams (40%) had a pH lower than 5.5 at baseflow. As elsewhere in Europe, acid deposition has decreased since the seventies, as has base cation deposition.
Angéli, Nicolas +9 more
core +4 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
EFFECTS OF LIME, VERMICOMPOST, AND BLENDED FERTILIZER ON MAIZE (ZEA MAYS L.) POSTHARVEST SELECTED SOIL CHEMICAL PROPERTIES IN ASSOSA DISTRICT, NORTH WESTERN ETHIOPIA [PDF]
Big Data in AgricultureIntegrated application of lime, vermicompost, and blended fertilizers are conducive to higher crop yields but its impacts on the nitisols of the study area have not been investigated.
Abdisa Abebe +3 more
doaj +1 more source