Results 131 to 140 of about 2,324,089 (344)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Temporal changes in chemical properties of acid soil profiles treated with magnesium limestone and gypsum [PDF]

open access: yes, 2010
Effects of ground magnesium limestone (GML) and gypsum on the properties of Ultisols at two sites, involving a corn groundnut rotation, were studied over 24 months.
Bell, L. C.   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Estimation of cation-exchange capacity in routine soil testing

open access: yesAgricultural and Food Science, 1986
The efficiency of the soil testing method used in Finland for predicting the effective cation-exchange capacity was studied in a material of 430 topsoil samples.
Raina Niskanen, Antti Jaakkola
doaj  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

Long-term fate of sewage-sludge derived cadmium in arable soils [PDF]

open access: yes, 2003
The focus of this work was to improve knowledge of the long-term fate of cadmium supplied to arable soils by sewage sludge. Emphasis was placed on measured and modelled changes in the solubility and mobility of cadmium, resulting from long-term turnover ...
Bergkvist, Petra
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Spatial Variability of Soil Acidity and Lime Requirements for Potato Cultivation in the Huánuco Highlands

open access: yesAgriculture
Soil acidity is a major limiting factor for potato production in Peru’s high Andean region. This study aims to predict the spatial variability of soil acidity as a fundamental tool for recommending site-specific liming treatments and to identify the ...
Kenyi Quispe   +5 more
doaj   +1 more source

Ameliorating effects of palm oil mill effluent on the chemical properties of soils and maize growth in pots [PDF]

open access: yes, 1995
Highly weathered Malaysian soils are mostly acidic having high Al saturation and low Ca and/or l\1g contents. A leaching experiment in PVC columns and a pot trial were carried out to alleviate these acid soil infertilities by application of palm oil ...
Jusop, Shamsuddin   +2 more
core  

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

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