Results 261 to 270 of about 43,942 (341)

Cubic Phase‐Inducible Zwitterionic Phospholipids Improve the Functional Delivery of mRNA

Advanced Science, EarlyView.
In this study, a chemically engineered zwitterionic phospholipids derived from 1,2‐dioleoyl‐3‐sn‐glycero‐phosphoethanolamine (DOPE), DOPE‐Cx, are designed. The DOPE‐Cx lipids induce a cubic phase upon mixing with phosphatidylcholine, facilitate membrane fusion‐mediated endosomal escape, and enhance the functional delivery of mRNA.
Kazuki Iwakawa, Rikako Sato, Mariko Konaka, Yuma Yamada, Hideyoshi Harashima, Yusuke Sato   +5 more
wiley   +1 more source

Xenon gas as a potential treatment for opioid use disorder, alcohol use disorder, and related disorders. [PDF]

Med Gas Res
Kaufman MJ, Meloni EG.
europepmc   +1 more source

The Type III Secretion System (T3SS) of Escherichia Coli Promotes Atherosclerosis in Type 2 Diabetes Mellitus

Advanced Science, EarlyView.
Large‐scale studies indicate a strong relationship between the gut microbiome, type 2 diabetes mellitus (T2DM), and atherosclerotic cardiovascular disease (ASCVD). Here, a higher abundance of the type III secretion system (T3SS) virulence factors of Enterobacteriaceae/Escherichia‐Shigella in patients with T2DM‐related‐ASCVD, which correlates with their
Yao‐Yuan Zhang, Song‐Tao Chen, Gang Chen, Le Zhou, Guo‐Liang Zhou, Xin‐Yuan Yu, Long Yuan, Wei‐Qian Deng, Zhen‐Bo Wang, Jing Li, Yi‐Fu Tu, Da‐Wei Zhang, Yuan li, Abdul Sammad, Xiao Zhu, Kai Yin   +15 more
wiley   +1 more source

The potential of muscarinic M₁ and M₄ receptor activators for the treatment of cognitive impairment associated with schizophrenia. [PDF]

Front Psychiatry
Yohn SE, Harvey PD, Brannan SK, Horan WP.   +3 more
europepmc   +1 more source

An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis

Advanced Science, EarlyView.
The study identifies agrin‐EGFR mechanotransduction as a critical driver of lung adenocarcinoma which enhances EGFR signaling through an integrin‐FAK‐actomyosin dependent positive feedback on YAP/TAZ ‐TEAD in response to matrix stiffness. Targeting this oncogenic loop through combinatorial treatments inhibits lung cancer due to agrin impairment.
Reza Bayat Mokhtari, Divyaleka Sampath, Paige Eversole, Melissa Ong Yu Lin, Dmitriy A. Bosykh, Gandhi T.K. Boopathy, Aravind Sivakumar, Cheng‐Chun Wang, Ramesh Kumar, Joe Yeong Poh Sheng, Ellen Karasik, Barbara A. Foster, Han Yu, Xiang Ling, Wenjie Wu, Fengzhi Li, Zoë Weaver Ohler, Christine F. Brainson, David W. Goodrich, Wanjin Hong, Sayan Chakraborty   +20 more
wiley   +1 more source

Histamine Modulation of the Basal Ganglia Circuitry in the Motor Symptoms of Parkinson's Disease. [PDF]

CNS Neurosci Ther
Zhu HX, Lou WW, Jiang YM, Ciobanu A, Fang CX, Liu CY, Yang YL, Cao JY, Shan L, Zhuang QX.   +9 more
europepmc   +1 more source

Effects of neuromodulators on synaptic transmission and excitability in frontal neocortex. [PDF]

, 2000
Chu, Zhiguo
core   +1 more source

Self‐Induced A‐B‐A Structure Enables Efficient Wide‐Bandgap Perovskite Solar Cells and Tandems

Advanced Science, EarlyView.
DMFP penetrates to the bottom of the perovskite, forming an A‐B‐A sandwich structure with BzMIM Br, leading to strong interactions with the perovskite. In the vertical direction, utilizing multisite coordination with Pb ions forms internal molecular bridges, which not only improves crystallographic orientation but also suppresses halide phase ...
Xixi Yu, Yong Zhu, Kunpeng Li, Xiong Chang, Mengni Zhou, Zhewen Xie, Xing Zhu, Hua Wang, Wenhui Ma, Shaoyuan Li, Tao Zhu   +10 more
wiley   +1 more source

Neuroanatomy of spinal nociception and pain in dogs and cats: a practical review for the veterinary clinician. [PDF]

Front Vet Sci
Pedersen TR, Berendt M, Rusbridge C.
europepmc   +1 more source