Results 281 to 290 of about 43,942 (341)

Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell‐Type Level

Advanced Science, EarlyView.
This study presents a comprehensive multi‐omics framework to uncover cell‐type‐specific regulatory networks in plant drought responses. By integrating transcriptomic, proteomic, and epigenetic data from nearly 30 000 samples, key regulators such as CIPK23 and NLP7 are identified, revealing insights into conserved drought tolerance mechanisms and ...
Moyang Liu, Yuanyuan Xu, Yue Song, Dongying Fan, Junpeng Li, Zhen Zhang, Lujia Wang, Juan He, Cheng Chen, Chao Ma   +9 more
wiley   +1 more source

Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases. [PDF]

Pharmacol Rep
Szpręgiel I, Bysiek A.
europepmc   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Drugs with glutamate-based mechanisms of action in psychiatry. [PDF]

Pharmacol Rep
Chrobak AA, Siwek M.
europepmc   +1 more source

Interface‐Confined Catalytic Synthesis of Anisotropic Covalent Organic Framework Nanofilm for Ultrafast Molecular Sieving

Advanced Science, EarlyView.
This study develops an innovative interface‐confined catalytic synthesis strategy to molecularly construct anisotropic Tp‐BD(OH)₂ COF membranes with record‐breaking pure water permeance of 525.3 L m−2 h−1 bar−1 and exceptional molecule/ion selective factor up to 648.6, opening up a new avenue for prestigious nanostructure regulation of COF membranes ...
Jiahao Tang, Yu Liao, Zhenxiang Pan, Songjun Fang, Mingxiu Tang, Lu Shao, Gang Han   +6 more
wiley   +1 more source

Targeting N-Methyl-d-Aspartate Receptors in Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Carles A, Freyssin A, Perin-Dureau F, Rubinstenn G, Maurice T.   +4 more
europepmc   +1 more source

Mannose‐Glycated Metal‐Phenolic Microcapsules Orchestrate Phenotype Switch of Macrophages for Boosting Tumor Immunotherapy

Advanced Science, EarlyView.
Immunomodulatory metal‐phenolic microcapsules (mMPMs) is developed in this study that leverages dopamine‐modified hyaluronic acid and FeIII assemble on mannose‐glycated bovine serum albumin microbubbles. mMPMs effectively promote macrophage internalization and M1 polarization, enhancing pro‐inflammatory responses.
Xin Tan, Renwang Sheng, Weikun Li, Yinghua Tao, Zonghao Liu, Ning Yang, Syeda Safia Hashmi, Feiling Feng, Fangzhou Liu, Liqin Ge   +9 more
wiley   +1 more source

Redefining Roles: A Paradigm Shift in Tryptophan-Kynurenine Metabolism for Innovative Clinical Applications. [PDF]

Int J Mol Sci
Tanaka M, Szabó Á, Vécsei L.
europepmc   +1 more source

NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models. [PDF]

Int J Mol Sci
Tumdam R, Hussein Y, Garin-Shkolnik T, Stern S.   +3 more
europepmc   +1 more source