Results 291 to 300 of about 44,335 (335)

Excitatory amino acid receptor subtypes and specific antagonists

Medicinal Research Reviews, 1989
Article de synthese sur le site de reconnaissance des recepteurs, le ionophore, l'unite modulatrice, les determinations du poids moleculaire, les ...
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Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphine

European Journal of Pharmacology, 1994
The effect of the non-selective antagonist of excitatory amino acid receptors kynurenic acid (50, 100 and 150 mg/kg, i.p.) on morphine-derived reward was studied in rats. Kynurenic acid dose dependently blocked the acquisition of morphine conditioned place preference when injected before conditioning.
A, Bespalov, M, Dumpis, L, Piotrovsky, E, Zvartau   +3 more
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Neurotoxicity and excitatory amino acid antagonists.

Neurotoxicology, 1995
The cytotoxic action of excitatory amino acids (glutamate, aspartate, NMDA, AMPA, and kainate) was studied in cultured neocortical neurons. It was demonstrated that all amino acids triggered an increase in the intracellular Ca2+ concentration which appeared to be prerequisite for their cytotoxic action.
A, Schousboe, A, Frandsen, P, Wahl, P, Krogsgaard-Larsen   +3 more
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Excitatory amino acid antagonists protect mice against seizures induced by bicuculline

Brain Research, 1990
The effects of excitatory amino acid antagonists on convulsions induced by intracerebroventricular (i.c.v.) or systemic (s.c.) administration of the gamma-aminobutyric acidA (GABAA) antagonist bicuculline (BIC) were tested in mice. 3-[+/-)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonate (CPP), 2-amino-7-phosphonoheptanoate (AP7) and (+)-5-methyl-10,11 ...
W A, Turski, E, Urbanska, M, Dziki, J, Parada-Turska, C, Ikonomidou   +4 more
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Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications

Pharmaceutica Acta Helvetiae, 2000
Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Specific receptors bind glutamate and some of these when activated open an integral ion channel and are thus known as ionotropic receptors. Within the ionotropic family of glutamate receptors, three major subtypes have been identified using classical ...
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Antagonists of excitatory amino acids and cyclic guanosine monophosphate in cerebellum

Neuropharmacology, 1982
The excitatory amino acid analogues kainate, quisqualate, domoic acid, 4-fluoroglutamate, homocysteic acid and N-methylaspartate as well as the tremor-inducing drugs harmaline and oxotremorine all induced significant elevations in cyclic guanosine monophosphate (cGMP) levels in the cerebellum in vivo. The putative antagonists of excitatory amino acids,
P L, Wood, J W, Richard, C, Pilapil, N P, Nair   +3 more
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Hyperpolarization of retinal horizontal cells by excitatory amino acid neurotransmitter antagonists

Neuroscience Letters, 1982
Membrane potentials of retinal horizontal cells have been recorded fro isolated fish retinae perfused with Ringer solutions containing various drugs. We show that glutamate diethyl ester (GDEE) and gamma-D-glutamylglycine (DGG), respectively antagonists of the excitatory neurotransmitter agonists quisqualate and kainate, hyperpolarize horizontal cells ...
J S, Rowe, K H, Ruddock
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Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

Clinical Science, 1985
The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry.
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Protective role of excitatory amino acid antagonists in experimental retinal ischemia

Graefe's Archive for Clinical and Experimental Ophthalmology, 1995
Excitatory amino acids and their analogues (NMDA, kainate and AMPA) are implicated in the pathogenesis of ischemic brain injury. In order to fully understand their involvement in the pathogenesis of retinal ischemic injury, we studied the electrophysiological and histopathological effects of two excitatory amino acid antagonists, cis-PDA and MK 801, in
M, Weber, N, Bonaventure, J A, Sahel
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Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists

Canadian Journal of Physiology and Pharmacology, 1985
The effectiveness of several excitatory amino acid antagonists to delay or block seizures induced by oxygen at high pressure was examined in mice. Of the antagonists tested, namely, L-proline, DL-α-aminoadipate, DL-2-amino-5-phosphonovalerate, and L-glutamic acid diethyl ester, DL-2-amino-5-phosphonovalerate was the most effective in delaying or ...
C A, Colton, J S, Colton
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