Results 291 to 300 of about 43,942 (341)

AMPA receptor diffusional trapping machinery as an early therapeutic target in neurodegenerative and neuropsychiatric disorders. [PDF]

Transl Neurodegener
Choquet D, Opazo P, Zhang H.
europepmc   +1 more source

The effect of traumatic brain injury on learning and memory: A synaptic focus. [PDF]

Neuroscientist
Eyolfson E, Suesser KRB, Henry H, Bonilla-Del Río I, Grandes P, Mychasiuk R, Christie BR.   +6 more
europepmc   +1 more source

Amelioration of Glutamate-induced Toxicity by a New Thyrotropin-releasing Hormone (TRH) Analogue PYR-l-(2,5-Dibromo)-His-l-ProNH₂. [PDF]

Ann Neurosci
Sunkara MR, Singh JN, Meena CL, Pant AB, Jain R, Sharma SS.   +5 more
europepmc   +1 more source

NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders. [PDF]

Pharmaceuticals (Basel)
Egunlusi AO, Joubert J.
europepmc   +1 more source

Isomers of cyclazocine as excitatory amino acid antagonists

Neuropeptides, 1984
Abstract As an N-methylaspartate antagonist on cat and frog spinal neurones, (−) cyclazocine was twice as potent as (+) cyclazocine. This stereoselectivity is similar to that of cyclazocine at sigma rather than at mu or kappa opiate receptors. Cyclazocine also reduced synaptic excitation in rat cortex.
David Lodge, Stephen C. Berry, John A. Church, David Martin, Amy McGhee, H. Lai, Alex M. Thomson   +6 more
openalex   +4 more sources

Agonists and antagonists for excitatory amino acid receptors

Trends in Neurosciences, 1987
Abstract Behind the recent explosion of interest in the field, there lies a long period of relatively slow progress in the characterization of excitatory amino acid receptors. In this article, Jeff Watkins and Harry Olverman summarize the emergence of current ideas relating to receptor differentiation and describe some of the molecular features of ...
J.C. Watkins, Henry J. Olverman
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6 Excitatory amino acid antagonists

Baillière's Clinical Anaesthesiology, 1996
Summary l -glutamate is a major excitatory neurotransmitter in the mammalian central nervous system. It acts through ion channel receptors of the AMPA and NMDA subtypes, and selective antagonists acting on these receptors are available. Both in vitro and in vivo animal studies have demonstrated that glutamate antagonists, particularly those acting ...
Kennedy R. Lees, Leslie L. Iversen
openaire   +2 more sources

Overview: Excitatory Amino Acid Antagonists

Current Opinion on Therapeutic Patents, 1992
(1992). Overview: Excitatory Amino Acid Antagonists. Current Opinion on Therapeutic Patents: Vol. 2, No. 8, pp. 1201-1221.
Paul D. Leeson, Michael Rowley
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Noncompetitive excitatory amino acid receptor antagonists

Trends in Pharmacological Sciences, 1990
In the first article in this series, Watkins, Krogsgaard-Larsen and Honoré outlined the structure-activity requirements at the receptor sites for excitatory amino acids in the mammalian CNS. The postsynaptic depolarizing actions of glutamate are thought to be mediated by NMDA, AMPA and kainate receptors. Here David Lodge and Kenneth M.
David Lodge, Kenneth M. Johnson
openaire   +3 more sources