Results 291 to 300 of about 70,307 (362)
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Methyltetrahydrofolate as an antagonist of excitatory amino acids on spinal neurones
European Journal of Pharmacology, 1982Folate and N5-methyl-5,6,7,8-tetrahydrofolate (MTHF) have been reported to have excitatory effects upon cortical neurones, possibly due to interaction with kainate receptors. On spinal neurones these compounds have been found inactive as excitants; however MTHF is a weak antagonist of kainate and N-methyl-D-aspartate excitations, and less effectively ...
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Excitatory amino acid receptor subtypes and specific antagonists
Medicinal Research Reviews, 1989Article de synthese sur le site de reconnaissance des recepteurs, le ionophore, l'unite modulatrice, les determinations du poids moleculaire, les ...
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Neurotoxicity and excitatory amino acid antagonists.
Neurotoxicology, 1995The cytotoxic action of excitatory amino acids (glutamate, aspartate, NMDA, AMPA, and kainate) was studied in cultured neocortical neurons. It was demonstrated that all amino acids triggered an increase in the intracellular Ca2+ concentration which appeared to be prerequisite for their cytotoxic action.
A, Schousboe +3 more
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Non-competitive antagonists of excitatory amino acid receptors
Trends in Neurosciences, 1987Abstract Non-competitive antagonists have become important tools for investigating the basic mechanisms of NMDA receptor function. Such compounds (e.g. MK-801, PCP) are thought to act at the level of the NMDA receptor-associated ion channel and many show a marked use-dependence in their antagonist properties.
John A. Kemp +2 more
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Interaction of ethanol with excitatory amino acid receptor antagonists in mice
European Journal of Pharmacology, 1999The purpose of the present study was to determine whether the motor impairment (myorelaxation/ataxia) induced by excitatory amino acid receptor antagonists was exaggerated by pretreatment with ethanol. The results were compared with those of gamma-aminobutyric acid(A) (GABA(A)) receptor positive modulators alone and in combination with ethanol.
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Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications
Pharmaceutica Acta Helvetiae, 2000Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). Specific receptors bind glutamate and some of these when activated open an integral ion channel and are thus known as ionotropic receptors. Within the ionotropic family of glutamate receptors, three major subtypes have been identified using classical ...
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Role of Excitatory Amino Acid Antagonists in the Management of Birth Asphyxia
Neonatology, 1992Birth asphyxia is an important cause of permanent neuro-developmental disability. Asphyxia sets in course a progression of intracellular events which culminates in neuronal death, and this process may take up to 48 h to complete. Entry of calcium into the neurone appears to be the key to the cell death, and it is known that during asphyxia, excessive ...
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Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters
Clinical Science, 1985The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry.
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Hyperpolarization of retinal horizontal cells by excitatory amino acid neurotransmitter antagonists
Neuroscience Letters, 1982Membrane potentials of retinal horizontal cells have been recorded fro isolated fish retinae perfused with Ringer solutions containing various drugs. We show that glutamate diethyl ester (GDEE) and gamma-D-glutamylglycine (DGG), respectively antagonists of the excitatory neurotransmitter agonists quisqualate and kainate, hyperpolarize horizontal cells ...
J S, Rowe, K H, Ruddock
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Neuroscience Letters, 1984
Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness.
A E, King, H V, Wheal
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Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness.
A E, King, H V, Wheal
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