Results 91 to 100 of about 179,338 (253)

G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices

Journal of Neuroscience, 1995
Synaptic activation in the presence of competitive (D,L-APV,CNQX) and noncompetitive (MK-801,GYKI-52466) ionotropic glutamate receptor antagonists induced fast (10–90% rise time of 15–30 msec) postsynaptic responses in CA3 pyramidal neurons from acute ...
L. Miller, J. Petrozzino, J. Connor
semanticscholar   +1 more source

State-dependent cell-type-specific membrane potential dynamics and unitary synaptic inputs in awake mice

eLife, 2018
The cellular and synaptic mechanisms driving cell-type-specific function during various cortical network activities and behaviors are poorly understood.
Aurélie Pala, Carl CH Petersen
doaj   +1 more source

Chronobiology of Epilepsy [PDF]

, 2008
A fine balance between neuronal excitation and inhibition governs the physiological state of the brain. It has been hypothesized that when this balance is lost as a result of excessive excitation or reduced inhibition, pathological states such as ...
Dong-Uk Hwang, Hector Sepulveda, Mark Spano, Paul Carney, Sachin S. Talathi, Tom Mareci, William Ditto   +6 more
core   +1 more source

Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate

Advanced Science
Nonsyndromic cleft lip and palate (NSCLP) is a common craniofacial malformation increasingly recognized to involve neurodevelopmental abnormalities, though the molecular basis remains unclear.
Liu‐Lin Xiong, Xin‐Wei Huang, Qiu‐Xia Xiao, Ying‐Gang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiu‐Lin Wang, Li‐Ren Huangfu, Ye‐Qing Fei, Yang‐Yang Zhao, Chen‐Yang Zhai, Ze‐Mian Chen, Shi‐Kun Yuan, Yu‐Ji Zhou, Xing‐Man He, Ting‐Ting Zhi, Xiao‐He Tian, Ting‐Hua Wang   +19 more
doaj   +1 more source

Heterosynaptic Regulation of α2A-Adrenoceptors on Glutamate/GABA Release in the Prefrontal Cortex of Rats

Biomedicines
Background/Objectives: Norepinephrine (NE) plays a crucial role in modulating cognitive processes via α2A-adrenoceptors (α2A-ARs) within the prefrontal cortex (PFC), an essential brain region responsible for higher cognitive functions.
Yaru Wei, Yuhan Jiao, Xiaoting He, Xiaodong Tao, Baoming Li, Xuehan Zhang   +5 more
doaj   +1 more source

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. [PDF]

, 2019
We generated cortical interneurons (cINs) from induced pluripotent stem cells derived from 14 healthy controls and 14 subjects with schizophrenia. Both healthy control cINs and schizophrenia cINs were authentic, fired spontaneously, received functional ...
Apud, Jose, Berman, Karen F, Bin Kim, Woong, Cho, Jun-Hyeong, Chung, Sangmi, Cohen, Bruce M, Cote, Sarah E, Coyle, Joseph T, Eggan, Kevin C, Eisenberg, Leonard M, Fukuda, Emi, Ghosh, Sulagna, Hirayama, Teruyoshi, Huang, Weihua, Kim, Hae-Young, Lanz, Thomas A, McPhie, Donna L, Moghadam, Alexander A, Nguyen, Christine, Ni, Peiyan, Noh, Haneul, Noyes, Elizabeth, Ongur, Dost, Park, James M, Park, Joshua J, Parsons, Teagan, Perlis, Roy H, Rapoport, Judith L, Shao, Zhicheng, Stanton, Patric K, Straub, Richard E, Weinberger, Daniel R, Xi, Hualin Simon, Yagi, Takeshi, Yin, Changhong, Zhao, Joyce, Zheng, Kelvin   +36 more
core   +1 more source

Neural Synaptic Simulation Based on ZnAlSnO Thin-Film Transistors

Micromachines
In the era of artificial intelligence, neuromorphic devices that simulate brain functions have received increasingly widespread attention. In this paper, an artificial neural synapse device based on ZnAlSnO thin-film transistors was fabricated, and its ...
Yang Zhao, Chao Wang, Laizhe Ku, Liang Guo, Xuefeng Chu, Fan Yang, Jieyang Wang, Chunlei Zhao, Yaodan Chi, Xiaotian Yang   +9 more
doaj   +1 more source

Measurements of excitatory postsynaptic potentials in the stretch reflex of normal subjects and spastic patients. [PDF]

, 1979
Takuya Noguchi, S. Homma, Yoshikata Nakajima   +2 more
openalex   +1 more source

Reduction by general anaesthetics of group Ia excitatory postsynaptic potentials and currents in the cat spinal cord. [PDF]

, 1989
Dimitri M. Kullmann, Ricardo Martín, Stephen Redman   +2 more
openalex   +1 more source

Excitatory amino acid transporters (EAATs) restrain nucleus tractus solitarii (nTS) activity induced by ionotropic and metabotropic glutamate receptor activation

Revista Cubana de Investigaciones Biomédicas, 2020
Introduction: Glutamate (Glu) is the primary excitatory amino acid neurotransmitter released from visceral afferents in the nTS. Glu binds to postsynaptic ionotropic glutamate receptors (iGluRs, AMPA or NMDA) to induce rapid phasic synaptic currents and ...
David D. Kline, Michael P. Matott, Diana Martinez   +2 more
doaj