Intensity and frequency are the two main properties of sound. The non-monotonic neurons in the auditory system are thought to represent sound intensity. The central nucleus of the inferior colliculus (ICC), as an important information integration nucleus
Yun Liu+5 more
doaj +1 more source
A compact aVLSI conductance-based silicon neuron [PDF]
We present an analogue Very Large Scale Integration (aVLSI) implementation that uses first-order lowpass filters to implement a conductance-based silicon neuron for high-speed neuromorphic systems. The aVLSI neuron consists of a soma (cell body) and a single synapse, which is capable of linearly summing both the excitatory and inhibitory postsynaptic ...
arxiv
Random Walks for Spike-Timing Dependent Plasticity [PDF]
Random walk methods are used to calculate the moments of negative image equilibrium distributions in synaptic weight dynamics governed by spike-timing dependent plasticity (STDP). The neural architecture of the model is based on the electrosensory lateral line lobe (ELL) of mormyrid electric fish, which forms a negative image of the reafferent signal ...
arxiv +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao+7 more
wiley +1 more source
Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury
Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and ...
Maria-Belen Perez-Ramirez+2 more
doaj
Associative memory model with long-tail-distributed Hebbian synaptic connections
The postsynaptic potentials of pyramidal neurons have a non-Gaussian amplitude distribution with a heavy tail in both hippocampus and neocortex. Such distributions of synaptic weights were recently shown to generate spontaneous internal noise optimal ...
Naoki eHiratani+6 more
doaj +1 more source
Multifaceted Changes in Synaptic Composition and Astrocytic Involvement in a Mouse Model of Fragile X Syndrome. [PDF]
Fragile X Syndrome (FXS), a common inheritable form of intellectual disability, is known to alter neocortical circuits. However, its impact on the diverse synapse types comprising these circuits, or on the involvement of astrocytes, is not well known. We
Madison, Daniel V+5 more
core +1 more source
A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons
We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid.
Graben, Peter beim, Rodrigues, Serafim
core +2 more sources
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Ingebretson, Anna E.+3 more
core +3 more sources
A highly robust double memristor based on a molybdenum oxide‐molybdenum sulfide/perovskite heterojunction is demonstrated. Good resistive switching behavior with an endurance of 100 cycles, high retention of 2·× 104 s, and ON/OFF ratio of ≈102 is reported to emulate successfully the biosynapse's behavior.
Gion Kalemai+17 more
wiley +1 more source