Results 181 to 190 of about 174,824 (351)

New insights into epileptic spasm generation and treatment from the TTX animal model

open access: yesEpilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann   +2 more
wiley   +1 more source

High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing. [PDF]

open access: yesNat Neurosci
Chen IW   +7 more
europepmc   +1 more source

Absence seizures: Update on signaling mechanisms and networks

open access: yesEpilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABA<sub>B</sub> Receptor Signaling. [PDF]

open access: yesJ Neurosci
Mäki-Marttunen T   +8 more
europepmc   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

open access: yesEpilepsia Open, EarlyView.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker   +3 more
wiley   +1 more source

Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells. [PDF]

open access: yesJ Neurosci
Layous R   +9 more
europepmc   +1 more source

Erratum to: Active decay of composite excitatory postsynaptic potentials in hippocampal slices from young rats

open access: bronze, 2003
Mikhail G. Dozmorov   +6 more
openalex   +1 more source

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