Results 191 to 200 of about 363,862 (308)

The impact of exogenous Oxytocin on visual cortex plasticity across different stages of visual development. [PDF]

Sci Rep
Sun Y, Wang X, Chen Y, Luan Z, Hao R.
europepmc   +1 more source

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

Altered synaptic homeostasis: a key factor in the pathophysiology of depression. [PDF]

Cell Biosci
Wang B, He T, Qiu G, Li C, Xue S, Zheng Y, Wang T, Xia Y, Yao L, Yan J, Chen Y.   +10 more
europepmc   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Illuminating LGI1 Seizure Mechanisms Using Novel Optical Techniques. [PDF]

Epilepsy Curr
Stafstrom CE.
europepmc   +1 more source

Effectiveness and safety of perampanel for pediatric patients with epilepsy: A real‐world study from China

Pediatric Investigation, EarlyView.
The 50% responder rate and seizure freedom rate after 6 months of PER treatment during routine clinical care were 70.4% and 22.1%, respectively. The 50% responder rates for the 3 age‐based cohorts were 64.5% in infants and young children, 73.4% in children and 69.2% in adolescents, and the Seizure‐freedom rates were 16.1%, 23.7% and 25.6% respectively.
Xiaohui Wang, Taoyun Ji, Maomao Liu, Xiaofei Wang, Zhixian Yang, Sanmei Wang, Liping Zou, Jiong Qin, Xiaotun Ren, Liankun Ren, Liri Jin, Jie Shi, Dantao Peng, Kui Chen, Jindong Dai, Nan Zhang, Jun Wang, Tianyu Song, Fang Fang, Yuehua Zhang, Qun Wang   +20 more
wiley   +1 more source

Neural Excitatory/Inhibitory Imbalance in Motor Aging: From Genetic Mechanisms to Therapeutic Challenges. [PDF]

Biology (Basel)
Chen X, Wang Y, Zhang Y, Li X, Zhang L, Gao S, Zhang C.   +6 more
europepmc   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Reaching the Goal: Superior Navigators in Late Adulthood Provide a Novel Perspective into Successful Cognitive Aging

Topics in Cognitive Science, Volume 15, Issue 1, Page 15-45, January 2023., 2023
Abstract Normal aging is typically associated with declines in navigation and spatial memory abilities. However, increased interindividual variability in performance across various navigation/spatial memory tasks is also evident with advancing age. In this review paper, we shed the spotlight on those older individuals who exhibit exceptional, sometimes
Ruojing Zhou, Tuğçe Belge, Thomas Wolbers   +2 more
wiley   +1 more source

Artificial optoelectronic synapses based on Ga2O3 metal–semiconductor–metal solar‐blind ultraviolet photodetectors with asymmetric electrodes for neuromorphic computing

Responsive Materials, EarlyView.
A Ga2O3‐based neuromorphic device is designed to mimic biological synapses and neural networks. The device exhibits learning and forgetting behaviors under UV light with high energy efficiency. Applied to image recognition tasks, it demonstrates significant potential for optoelectronic artificial intelligence applications.
Huazhen Sun, Bingjie Ye, Mei Ge, Biao Gong, Leyang Qian, Irina N. Parkhomenko, Fadei F. Komarov, Yu Liu, Guofeng Yang   +8 more
wiley   +1 more source