Results 211 to 220 of about 363,862 (308)

Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13. [PDF]

Elife
Liu H, Li L, Wang J, Hu J, Xia J, Yu X, Tang J, Liu H, Yang X, Ma C, Kang L, Hu Z.   +11 more
europepmc   +1 more source

Low‐Power Optoelectronic Synaptic Transistors with Multimodal Neuromorphic Computation and Retinal‐Inspired Multiband Optical Binary Communication

Small Science, EarlyView.
A natural dextran film that is intrinsically green and transparent is employed as the dielectric for the optoelectronic synaptic transistors (OSTs) with the function of sensing, memorizing, and processing. The multimodal neuromorphic computation, visual adaptation ability, and retina‐inspired multiband optical binary (0 and 1) communication can be ...
Bo Huang, Linfeng Lan, Jiayi Pan, Fuzheng Qi, Jing Li, Churou Wang, Yaping Li, Dechun Zeng, Jiale Huang, Jintao Xu, Junbiao Peng   +10 more
wiley   +1 more source

A connectome manipulation framework for the systematic and reproducible study of structure-function relationships through simulations. [PDF]

Netw Neurosci
Pokorny C, Awile O, Isbister JB, Kurban K, Wolf M, Reimann MW.   +5 more
europepmc   +1 more source

Light‐Induced Radix Modulation and Optoelectronic Synaptic Properties in Ternary‐Logic Devices

Small Structures, EarlyView.
This article presents a multivalued logic (MVL) device that performs light‐induced radix modulation and synaptic functions. The proposed MVL device exhibits ternary‐logic states (OFF, intermediate, and ON) via Fowler–Nordheim tunneling as well as binary‐logic states upon irradiation with specific UV wavelengths.
Chohyeon Park, Jung Wook Lim
wiley   +1 more source

The effect of cannabinoid type Ⅱ receptor on the excitability of substantia nigra dopaminergic neurons. [PDF]

Front Pharmacol
Zhao S, Liu S, Gong Y, Ma Z.
europepmc   +1 more source

Physical Exercise Decreases Complement‐Mediated Synaptic Loss and Protects Against Cognitive Impairment by Inhibiting Microglial Tmem9‐ATP6V0D1 in Alzheimer's Disease

Aging Cell, EarlyView.
In a 5xFAD mouse model, we observed that physical exercise reduced the levels of microglial Tmem9, thereby inhibiting complement activation through its interaction with ATP6V0D1. Consequently, this attenuation of complement‐dependent synaptic loss led to significant improvements in both emotional and cognitive impairments. ABSTRACT Physical exercise is
Shiyin Li, Mingyue Li, Ge Li, Lili Li, Xiaofeng Yang, Zejie Zuo, Liying Zhang, Xiquan Hu, Xiaofei He   +8 more
wiley   +1 more source

Inhibitory specificity from a connectomic census of mouse visual cortex. [PDF]

Nature
Schneider-Mizell CM, Bodor AL, Brittain D, Buchanan J, Bumbarger DJ, Elabbady L, Gamlin C, Kapner D, Kinn S, Mahalingam G, Seshamani S, Suckow S, Takeno M, Torres R, Yin W, Dorkenwald S, Bae JA, Castro MA, Halageri A, Jia Z, Jordan C, Kemnitz N, Lee K, Li K, Lu R, Macrina T, Mitchell E, Mondal SS, Mu S, Nehoran B, Popovych S, Silversmith W, Turner NL, Wong W, Wu J, Reimer J, Tolias AS, Seung HS, Reid RC, Collman F, da Costa NM.   +40 more
europepmc   +1 more source

The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity

Aging Cell, EarlyView.
The effect of advancing age and intraocular pressure injury on retinal ganglion cell function and synaptic connectivity. While young mice modulate their synaptic input to recover retinal ganglion cell function following injury, older mice compensate by altering their action potential threshold and axon initial segment (AIS) length to increase intrinsic
Vicki Chrysostomou, Sevannah Ellis, Lewis E. Fry, Robert J. Hatch, Eamonn T. Fahy, Katharina C. Bell, Ian A. Trounce, Peter van Wijngaarden, Steve Petrou, Jonathan G. Crowston   +9 more
wiley   +1 more source

Cortical Potentiation in Chronic Neuropathic Pain and the Future Treatment. [PDF]

Pharmaceuticals (Basel)
Hao S, Lin S, Tao W, Zhuo M.
europepmc   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

Aging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik, Ádám Nyúl‐Tóth, Rafal Gulej, Roland Patai, Tamas Kiss, Jordan Delfavero, Raghavendra Y. Nagaraja, Priya Balasubramanian, Santny Shanmugarama, Anna Ungvari, Siva Sai Chandragiri, Kiana Vali Kordestan, Mark Nagykaldi, Peter Mukli, Andriy Yabluchanskiy, Sharon Negri, Stefano Tarantini, Shannon Conley, Tae Gyu Oh, Zoltan Ungvari, Anna Csiszar   +20 more
wiley   +1 more source