Results 231 to 240 of about 141,800 (341)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Roles of synaptic cell adhesion molecules in the neuromodulatory systems. [PDF]

Mol Cells
Li J, Kawasawa YI, Uchigashima M, Futai K.   +3 more
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

Exposure to β-hydroxybutyrate reduces the operating set point and increases excitability in hippocampal circuitry of healthy mice. [PDF]

Front Pharmacol
Zampieri TT, Higa GSV, Borges FS, Viana FJC, Cruvinel E, Bentivoglio LE, Lugao AB, Ulrich H, Britto LR, Katti KV, Chesne AM, de Pasquale R.   +11 more
europepmc   +1 more source

Calcium transients in dendrites of neocortical neurons evoked by single subthreshold excitatory postsynaptic potentials via low-voltage-activated calcium channels.

, 1994
Henry Markram, Bert Sakmann
openalex   +2 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Dopamine enhances both electrotonic coupling and chemical excitatory postsynaptic potentials at mixed synapses.

, 1992
Arrate Pereda, Antoine Triller, Henri Korn, D. S. Faber   +3 more
openalex   +2 more sources

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Impaired excitability of fast-spiking neurons in a novel mouse model of <i>KCNC1</i> epileptic encephalopathy. [PDF]

Elife
Wengert ER, Liebergall SR, Jimenez T, Cheng MA, Markwalter KH, Clatot J, Hong Y, Arias L, Marsh ED, Zhang X, Tsetsenis T, Somarowthu A, Akizu N, Goldberg EM.   +13 more
europepmc   +1 more source

Dopamine D-1 receptor-mediated inhibition of excitatory postsynaptic potentials in cultured striatal neurons.

, 1994
Hisamitsu Ujihara, Yutaka Tamura, Noritaka Nakata, Yasue Yamada, Takashi Ban, Masashi Sasa, Akinori Akaike   +6 more
openalex   +1 more source