Results 241 to 250 of about 174,824 (351)

Cellular and circuit features distinguish mouse dentate gyrus semilunar granule cells and granule cells activated during contextual memory formation. [PDF]

Elife
Dovek L, Ahmadi M, Marrero K, Zagha E, Santhakumar V.   +4 more
europepmc   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review. [PDF]

CNS Neurosci Ther
Huang M, Luo L, Wang W, Xu H, Chen M, Ma X, Xu T.   +6 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity. [PDF]

Cell Mol Life Sci
Pytyś A, Ijaz R, Buszka A, Miłek J, Figiel I, Wardaszka-Pianka P, Roszkowska M, Mierzwa N, Wojtas A, Kerstein E, Serwa R, Kalita K, Dzakpasu R, Dziembowska M, Włodarczyk J, Wójtowicz T.   +15 more
europepmc   +1 more source

Elucidation of the zinc binding site in KCNQ channels

British Journal of Pharmacology, EarlyView.
Background and Purpose KCNQ1‐5 (Kv7.1–7.5) are members of a family of voltage‐gated potassium channels with prominent function in the nervous and cardiovascular systems and in epithelia. KCNQ channels are activated by intracellular free zinc, but the molecular mechanism of this effect is poorly understood and zinc binding sites within KCNQ channels are
Shuo Zhang, Xinhe Yang, Meng Yang, Yixue Cao, Sai Shi, Nikita Gamper, Haixia Gao   +6 more
wiley   +1 more source

The emergence of electrical activity in human brain organoids. [PDF]

Stem Cell Reports
Mancinelli S, Bariselli S, Lodato S.
europepmc   +1 more source

Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology

British Journal of Pharmacology, EarlyView.
Theorized mechanism of dopamine homeostasis restoration in the nucleus accumbens core induced by a psychedelic intervention. Abstract Psychedelics have garnered great attention in recent years as treatments for major depressive disorder (MDD) and treatment‐resistant depression because of their ability to alter consciousness and afflicted cognitive ...
Lucas Wittenkeller, Gary Gudelsky, T. John Winhusen, Davide Amato   +3 more
wiley   +1 more source

The development of functional glutamatergic and GABAergic synaptic connections between vestibulo-ocular projection neurons and oculomotor motoneurons in the chicken embryo. [PDF]

Front Neurol
Mochida H, Glover JC.
europepmc   +1 more source

Myeloid PD‐1 Regulates Astrocyte Development and Leads to Active Behaviours

Cell Proliferation, EarlyView.
During early neurodevelopment, PD‐1 ablation in myeloid cells influences myeloid proliferation/differentiation and causes sustained astrocyte overproliferation. PD‐1f/f; LysM‐Cre mice showed elevated astrocyte gene expression and behavioural changes.
Jie Qin, Chong Wang, Sihan Li, Yanyan Wang, Tingting He, Jianwei Jiao, Fen Ji   +6 more
wiley   +1 more source