Results 241 to 250 of about 363,862 (308)

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Associative plasticity of granule cell inputs to cerebellar Purkinje cells. [PDF]

Elife
Conti R, Auger C.
europepmc   +1 more source

Chronic optogenetic stimulation of dentate gyrus granule cells in mouse organotypic slice cultures synaptically drives mossy cell degeneration

Epilepsia, EarlyView.
Abstract Objective Degeneration of hilar mossy cells in the dentate gyrus is an important hallmark of hippocampal sclerosis and is often observed in patients with temporal lobe epilepsy. To understand the pathogenesis of hippocampal sclerosis and develop novel neuroprotective treatments, it is critical to determine the mechanistic processes of mossy ...
Carolin Christina Koretz, Rebecca Schneider, Tassilo Jungenitz, Alexander Drakew, Jochen Roeper, Thomas Deller   +5 more
wiley   +1 more source

Connectomics of predicted Sst transcriptomic types in mouse visual cortex. [PDF]

Nature
Gamlin CR, Schneider-Mizell CM, Mallory M, Elabbady L, Gouwens N, Williams G, Mukora A, Dalley R, Bodor AL, Brittain D, Buchanan J, Bumbarger DJ, Joyce E, Kapner D, Kinn S, Mahalingam G, Seshamani S, Takeno M, Torres R, Yin W, Nicovich PR, Bae JA, Castro MA, Dorkenwald S, Halageri A, Jia Z, Jordan C, Kemnitz N, Lee K, Li K, Lu R, Macrina T, Mitchell E, Mondal SS, Mu S, Nehoran B, Popovych S, Silversmith W, Turner NL, Wong W, Wu J, Yu SC, Berg J, Jarsky T, Lee B, Seung HS, Zeng H, Reid RC, Collman F, da Costa NM, Sorensen SA.   +50 more
europepmc   +1 more source

The universal role of adaptive transcription in health and disease

The FEBS Journal, EarlyView.
Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley   +1 more source

Mechanisms of glutamate receptors hypofunction dependent synaptic transmission impairment in the hippocampus of schizophrenia susceptibility gene Opcml-deficient mouse model. [PDF]

Mol Brain
Sun X, Meng H, Lu T, Yue W, Zhang D, Wang L, Li J.   +6 more
europepmc   +1 more source

Role of brain-derived neurotrophic factor in dysfunction of short-term to long-term memory transformation after surgery and anaesthesia in older mice. [PDF]

Br J Anaesth
Liu Q, Wang HB, Lin JT, Jiao XH, Liu YP, Li TZ, Xie Z, Zhou CH, Wu YQ, Miao HH.   +9 more
europepmc   +1 more source

Estrogenic regulation of hippocampal inhibitory system across lifespan

Journal of Neuroendocrinology, EarlyView.
Abstract Estrogens produced in peripheral tissues and locally in the brain are potent neuromodulators. The function of the hippocampus, a brain region essential for episodic memory and spatial navigation, relies on the activity of ensembles of excitatory neurons whose activity is temporally and spatially coordinated by a wide diversity of inhibitory ...
Pablo Méndez, Rut de la Vega‐Ruiz, Alberto Montes‐Mellado   +2 more
wiley   +1 more source

Kisspeptin fiber and receptor distribution analysis suggests its potential role in central sensorial processing and behavioral state control

Journal of Neuroendocrinology, EarlyView.
Abstract Kisspeptin (KP) signaling in the brain is defined by the anatomical distribution of KP‐producing neurons, their fibers, receptors, and connectivity. Technological advances have prompted a re‐evaluation of these chemoanatomical aspects, originally studied in the early years after the discovery of KP and its receptor Kiss1r.
Limei Zhang, Vito Salvador Hernández, Mario Alberto Zetter, Oscar Rene Hernández‐Pérez, Rafael Hernández‐González, Ignacio Camacho‐Arroyo, Lee E. Eiden, Robert P. Millar   +7 more
wiley   +1 more source