Results 61 to 70 of about 179,338 (253)

Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats

Iranian Journal of Medical Sciences, 2016
Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown.
Chengdong Yuan, Yajun Zhang, Yu Zhang, Song Cao, Yuan Wang, Bao Fu, Tian Yu   +6 more
doaj  

Mild Traumatic Brain Injury Evokes Pyramidal Neuron Axon Initial Segment Plasticity and Diffuse Presynaptic Inhibitory Terminal Loss

Frontiers in Cellular Neuroscience, 2017
The axon initial segment (AIS) is the site of action potential (AP) initiation, thus a crucial regulator of neuronal activity. In excitatory pyramidal neurons, the high density of voltage-gated sodium channels (NaV1.6) at the distal AIS regulates AP ...
Michal Vascak, Jianli Sun, Matthew Baer, Kimberle M. Jacobs, John T. Povlishock   +4 more
doaj   +1 more source

A biophysical observation model for field potentials of networks of leaky integrate-and-fire neurons

, 2012
We present a biophysical approach for the coupling of neural network activity as resulting from proper dipole currents of cortical pyramidal neurons to the electric field in extracellular fluid.
Graben, Peter beim, Rodrigues, Serafim
core   +2 more sources

Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits [PDF]

, 2018
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can efficiently incorporate optically active photoluminescent centers such as the nitrogen-vacancy complex, thus making them promising candidates as optical biolabels and drug-delivery ...
Battiato, A., Calorio, C., Carabelli, V., Carbone, E., Forneris, J., Gai, M., Gavello, D., Genovese, M., Guarina, L., Marcantoni, A., Moreva, E., Olivero, P., Picollo, F., Tchernij, S. Ditalia, Traina, P.   +14 more
core   +4 more sources

GABAB Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation

Cells, 2018
During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons.
Jinbin Tian, Michael X. Zhu
doaj   +1 more source

Enhancement of synchronization in a hybrid neural circuit by spike timing dependent plasticity [PDF]

, 2003
Synchronization of neural activity is fundamental for many functions of the brain. We demonstrate that spike-timing dependent plasticity (STDP) enhances synchronization (entrainment) in a hybrid circuit composed of a spike generator, a dynamic clamp ...
Abarbanel, Henry D I, Nowotny, Thomas, Rabinovich, Mikhail I, Selverston, Allan I, Zhigulin, Valentin P   +4 more
core   +2 more sources

Exercise-Induced Fatigue Impairs Bidirectional Corticostriatal Synaptic Plasticity

Frontiers in Cellular Neuroscience, 2018
Exercise-induced fatigue (EF) is a ubiquitous phenomenon in sports competition and training. It can impair athletes’ motor skill execution and cognition.
Jing Ma, Huimin Chen, Xiaoli Liu, Lingtao Zhang, Decai Qiao   +4 more
doaj   +1 more source

Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects [PDF]

, 2015
The CRF system of the central nucleus of the amygdala (CeA) is important for the processing of anxiety, stress, and effects of acute and chronic ethanol.
CICCOCIOPPO, Roberto, Heilig, Markus, Herman, Melissa A, Kirson, Dean, Luu, George, Oleata, Christopher S, Roberto, Marisa, Varodayan, Florence P   +7 more
core   +1 more source

Bayesian inference of synaptic quantal parameters from correlated vesicle release

Frontiers in Computational Neuroscience, 2016
Synaptic transmission is both history-dependent and stochastic, resulting in varying responses to presentations of the same presynaptic stimulus. This complicates attempts to infer synaptic parameters and has led to the proposal of a number of different ...
Alexander D Bird, Alexander D Bird, Alexander D Bird, Mark J Wall, Magnus J E Richardson   +4 more
doaj   +1 more source

Meta-Potentiation: Neuro-Astroglial Interactions Supporting Perceptual Consciousness [PDF]

, 2007
Conscious perceptual processing involves the sequential activation of cortical networks at several brain locations, and the onset of oscillatory synchrony affecting the same neuronal population.
Alfredo Pereira Jr, Fá
core   +2 more sources