Long-term potentiation in frontal cortex: Role of NMDA-modulated polysynaptic excitatory pathways [PDF]
, 1989 The present study examined the role of N-methyl-D-aspartic acid (NMDA) receptors in synaptic plasticity in regular-spiking cells of rat frontal cortex. Intracortical stimulation, at levels subthreshold for elicitation of action potentials, evoked a late ...
Hablitz, John H., Sutor, Bernd
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Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory
Frontiers in Molecular Neuroscience, 2023 The postsynaptic inhibition through GABAA receptors (GABAAR) relies on two mechanisms, a shunting effect due to an increase in the postsynaptic membrane conductance and, in mature neurons, a hyperpolarization effect due to an entry of chloride into ...
Anna Kreis +10 more
doaj +1 more source
The effect of heterogeneity on decorrelation mechanisms in spiking neural networks: a neuromorphic-hardware study [PDF]
, 2014 High-level brain function such as memory, classification or reasoning can be realized by means of recurrent networks of simplified model neurons. Analog neuromorphic hardware constitutes a fast and energy efficient substrate for the implementation of ...
Diesmann, Markus +6 more
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The Functional Organization of Neocortical Networks Investigated in Slices with Local Field Recordings and Laser Scanning Photostimulation. [PDF]
PLoS ONE, 2015 The organization of cortical networks can be investigated functionally in brain slices. Laser scanning photostimulation (LSPS) with glutamate-uncaging allows for a rapid survey of all connections impinging on single cells recorded in patch-clamp.
Melissa A Erlandson +2 more
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Optimal Spike-Timing Dependent Plasticity for Precise Action Potential Firing [PDF]
arXiv, 2005 In timing-based neural codes, neurons have to emit action potentials at precise moments in time. We use a supervised learning paradigm to derive a synaptic update rule that optimizes via gradient ascent the likelihood of postsynaptic firing at one or several desired firing times.
arxiv
Activity-dependent release of Adenosine: a critical re-evaluation of mechanism [PDF]
, 2008 Adenosine is perhaps the most important and universal modulator in the brain. The current consensus is that it is primarily produced in the extracellular space from the breakdown of previously released ATP.
Dale, Nicholas, Wall, Mark J.
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Scientific ReportsSensory stimulations at 40 Hz gamma (but not any other frequency), have shown promise in reversing Alzheimer’s disease (AD)-related pathologies. What distinguishes 40 Hz?
Aayushi A. Patel +3 more
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Chronobiology of Epilepsy [PDF]
, 2008 A fine balance between neuronal excitation and inhibition governs the physiological state of the brain. It has been hypothesized that when this balance is lost as a result of excessive excitation or reduced inhibition, pathological states such as ...
Dong-Uk Hwang +6 more
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Firing Cell: An Artificial Neuron with a Simulation of Long-Term-Potentiation-Related Memory [PDF]
ISAROB 2006, pp.731-734, 2017 We propose a computational model of neuron, called firing cell (FC), properties of which cover such phenomena as attenuation of receptors for external stimuli, delay and decay of postsynaptic potentials, modification of internal weights due to propagation of postsynaptic potentials through the dendrite, modification of properties of the analog memory ...
arxiv
Corticostriatal Transmission Is Selectively Enhanced in Striatonigral Neurons with Postnatal Loss of Tsc1. [PDF]
, 2018 mTORC1 is a central signaling hub that integrates intra- and extracellular signals to regulate a variety of cellular metabolic processes. Mutations in regulators of mTORC1 lead to neurodevelopmental disorders associated with autism, which is ...
Bateup, Helen S +2 more
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