Results 221 to 230 of about 82,251 (326)

Cabergoline, Dopamine D2 Receptor Agonist, Prevents Neuronal Cell Death under Oxidative Stress via Reducing Excitotoxicity

, 2014
Haruki Odaka, Tadahiro Numakawa, Naoki Adachi, Yoshiko Ooshima, Shingo Nakajima, Yusuke Katanuma, Takafumi Inoue, Hiroshi Kunugi   +7 more
openalex   +2 more sources

Current Concepts of Excitotoxicity [PDF]

Journal of Neuropathology and Experimental Neurology, 1996
openaire   +2 more sources

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

Inhibition of Mettl3-mediated m6A RNA modification of HMGCS1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma. [PDF]

Int J Surg
Wang C, Feng L, Fang W, Zhang C, Zhang W, Zhu W, He Y, Xia Z, Song W, Xia X.   +9 more
europepmc   +1 more source

Transient domoic acid excitotoxicity increases BDNF expression and activates both MEK- and PKA-dependent neurogenesis in organotypic hippocampal slices [PDF]

, 2013
Anabel Pérez‐Gómez, R. Andrew Tasker
openalex   +1 more source

Decoding the Therapeutic Effects of Acupuncture in Hemorrhagic Stroke Using Single‐Cell RNA Sequencing

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The graphical abstract delineates the mechanisms by which acupuncture mitigates the effects of hemorrhagic stroke through the modulation of glial cells. Central to these mechanisms are APOE‐TREM2‐mediated microglial activation, astrocyte‐mediated neuroprotection, and oligodendrocyte‐driven myelination, which collectively enhance functional recovery ...
Chen Ruan, Jia Du, Wentao Zhang, Jiacheng Song, Peipei Feng, Jiajun Shi, Kelang Lou, Yuqiang Lu, Xinwei Li, Zhongwei Guo, Hao Liu   +10 more
wiley   +1 more source

NMDA receptors in neurodegenerative diseases: mechanisms and emerging therapeutic strategies. [PDF]

Front Aging Neurosci
Zhang K, Wen M, Nan X, Zhao S, Li H, Ai Y, Zhu H.   +6 more
europepmc   +1 more source

Vascular Endothelial Growth Factor Prevents Paralysis and Motoneuron Death in a Rat Model of Excitotoxic Spinal Cord Neurodegeneration [PDF]

, 2007
Luis B. Tovar‐y‐Romo, Angélica Zepeda, Ricardo Tapia   +2 more
openalex   +1 more source

Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
This study elucidates the central role of transient receptor potential (TRP) channels in driving neuroinflammation across neurological disorders. Acting as critical molecular sensors on neurons and glial cells, TRP channels' activation initiates downstream pathways that promote the release of proinflammatory cytokines, a pathological mechanism in ...
Daji Guo, Mengjiao Cai, Yanmin Xian, Yinyin Chen, Yujun Feng, Chun Hu, Lizhang Zeng, Lei Shi, Shiqing Zhang   +8 more
wiley   +1 more source

Toward a Unified Framework in Molecular Neurobiology of Alzheimer's Disease: Revisiting the Pathophysiological Hypotheses. [PDF]

Mol Neurobiol
Hein ZM, Karikalan B, Gopalakrishna PK, Dhevi K, Alkatiri A, Hussan F, Mohd Moklas MA, Jagadeesan S, Che Ramli MD, Che Mohd Nassir CMN, Vishnumukkala T.   +10 more
europepmc   +1 more source