Glia, Volume 74, Issue 1, January 2026.TDP‐43Q331K mice exhibit altered proliferative dynamics in oligodendrocytes and their precursors. Oligodendroglial cell death is evident in TDP‐43Q331K mice. TDP‐43Q331K mice display altered myelin reflectance and pathology in the spinal cord. ABSTRACT Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by the ...
Katherine N. Lewis +8 more
wiley +1 more source
Human Brain Mapping, Volume 47, Issue 1, January 2026.A computational laminar model links fast interneuron dysfunction to early hyperexcitability and late hypoactivity in Alzheimer's disease, reproducing key M/EEG biomarkers and capturing the disease's biphasic electrophysiological progression. ABSTRACT Early‐stage AD involves cortical hyperexcitability, progressing to oscillatory slowing and hypoactivity.
Roser Sanchez‐Todo +5 more
wiley +1 more source
Combined Preventive and Preconditioning Treatments for the Comorbidity of Alzheimer's Disease and Ischemic Stroke in a GluN3A Knockout Mouse and a 5xFAD Mouse. [PDF]
CellsYu SP +6 more
europepmc +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 1, January 2026.ABSTRACT Background Spinal cord injury (SCI) leads to severe neurological dysfunction. Current therapeutic strategies remain limited, with poor recovery rates. Oxidative stress and ferroptosis are key mechanisms underlying secondary SCI. Paeoniflorin has anti‐inflammatory, antioxidant, and neuroprotective properties; however, its role in regulating ...
Zongyu Zhang +3 more
wiley +1 more source
Regulation of L-Lactate in Glutamate Excitotoxicity Under Cerebral Ischemia: Pathophysiology and Preventive Strategy. [PDF]
Pharmaceuticals (Basel)Zhang M +5 more
europepmc +1 more source
Sciatic Nerve Stimulation Mitigates Depression‐Like Behaviors and Memory Deficits in Stressed Mice
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 1, January 2026.ABSTRACT Stress causes depression and cognitive decline. With limitations in pharmacotherapy, sciatic nerve stimulation (SNS) offers a promising nondrug alternative. This study aimed to explore the therapeutic efficacy of SNS in mitigating stress‐induced depressive behaviors and memory deficits by focusing on astrocytic dysfunction and cellular ...
Chih‐Hao Tien +10 more
wiley +1 more source
Exploring the neuroprotective effects and underlying mechanisms of medical cannabinoids in ischemic stroke: a systematic meta-analysis with bibliometric mapping of cerebral ischemia research. [PDF]
Front NeurosciLi X, Wen L, Du Y, Fan X, Xue N, Qu M.
europepmc +1 more source
Lifestyle and Behavioural Intervention Therapy for Enhanced Hippocampal Neuroplasticity
Lifestyle Medicine, Volume 7, Issue 1, January 2026.ABSTRACT Background The neurogenic and neuroplastic capability of the brain plays a crucial role in mitigating responses to internal and external environmental stimuli. However, this process is inhibited in obesity, neurodegenerative and psychological disorders, the prevalence of which has increased on a global scale.
Ebrahim Samodien +4 more
wiley +1 more source
Surgical excision of cerebral glioma and multimodal treatment including Cerebrolysin: a case report. [PDF]
J Med LifeGonzález JDSR, Tapia A.
europepmc +1 more source