Results 291 to 300 of about 80,747 (355)

Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury

Neuron, 2022
SUMMARY Excitotoxicity induced by NMDA receptor (NMDAR) is a major cause of neuronal death in ischemic stroke. However, past efforts of directly targeting NMDARs have unfortunately failed in clinical trials.
Jianlin Feng, Zhichao Yue, Yunfeng Li
exaly   +2 more sources

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

Frontiers in Neuroscience, 2020
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials.
Dennis W Choi, Choi Dennis W
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update

Acta Pharmacologica Sinica
Glutamate excitotoxicity is intricately linked to the pathogenesis of neurodegenerative diseases, exerting a profound influence on cognitive functions such as learning and memory in mammals.
Zheng-Hong Qin, Qin Zheng-Hong
exaly   +2 more sources

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

Acta Pharmacologica Sinica, 2009
A pivotal role for excitotoxicity in neurodegenerative diseases is gaining increasingly more acceptance, but the underlying mechanisms through which it participates in neurodegeneration still need further investigation.
Zheng-Hong Qin, Qin Zheng-Hong
exaly   +2 more sources

Excitotoxicity in ALS

Neurology, 1996
This review will summarize current understanding of the molecular and cellular mechanisms of excitotoxicity, the organization of glutamate systems in relation to ALS and evidence that excitotoxicity is relevant to the pathogenesis of ALS.
P N, Leigh, B S, Meldrum
openaire   +2 more sources

Excitotoxicity and mitochondria

Biochemical Society Symposia, 1999
Excitotoxicity is the process whereby a massive glutamate release in the central nervous system in response to ischaemia or related trauma leads to the delayed, predominantly necrotic death of neurons. Excitotoxicity is also implicated in a variety of slow neurodegenerative disorders.
D G, Nicholls, S L, Budd, M W, Ward, R F, Castilho   +3 more
openaire   +2 more sources

Excitotoxicity as a Target against Neurodegenerative Processes.

Current pharmaceutical design, 2020
The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population. Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as to the injury and ...
Octavio Binvignat, J. Olloquequi
semanticscholar   +1 more source

CELL DAMAGE/EXCITOTOXICITY | Excitotoxicity and Neurodegenerative Disease

2009
Excitotoxicity is an established mechanism of neuronal killing. Many neurodegenerative diseases, including epilepsy, have implicated excitotoxicity in their pathogenesis. Studies characterizing excitotoxic mechanisms in these diseases have subsequently focused on studying aspects of glutamate transporters and/or receptors.
Tannenberg, R. K., Dodd, P. R.
openaire   +2 more sources

Excitotoxicity and neurodegenerative diseases

Current Opinion in Neurology, 1995
Glutamate is an excitatory neurotransmitter in the mammalian central nervous system and a neurotoxin (excitotoxin) that has the potential to destroy neurones by activation of ionotropic receptors. In contrast to the well documented role of glutamate in the pathogenesis of neuronal degeneration resulting from hypoxia/ischaemia, hypoglycaemia, status ...
C, Ikonomidou, L, Turski
openaire   +2 more sources